Liu Yuchen, Fu Houxin, Sun Jingxuan, Zhang Rongting, Zhong Yi, Yang Tianquan, Han Yong, Xiang Yongjun, Yuan Bin, Zhou Ruxuan, Chen Min, Wang Hangzhou
Department of Neurosurgery, Children's Hospital of Soochow University, Suzhou, 215006, Jiangsu, China.
Department of Pediatric Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, 215006, China.
Sci Rep. 2025 Apr 2;15(1):11230. doi: 10.1038/s41598-025-95784-3.
Infants and toddlers with mild traumatic brain injury (mTBI) and minor subdural hematoma (SDH) were found to have a higher risk of requiring neurosurgical intervention (NI). However, the ability to identify patients with mTBI and minor SDH who require NI remains limited. This study aims to develop a nomogram to predict NI in these patients. A nomogram predicting NI was established using demographic, clinical, radiographic, and laboratory data from patients with mTBI and minor SDH. The least absolute shrinkage and selection operator (LASSO) regression and best subsets regression (BSR) methods were employed to identify variables and select predictive factors. A nomogram was constructed using multivariable logistic regression. The model's performance was evaluated using the area under the receiver operating characteristic curve, calibration curves, the Hosmer-Lemeshow test, and decision curve analysis. Immediate seizures, anemia, and subarachnoid space depth were identified as significant predictive factors by the BSR, leading to the development of a nomogram. The AUC for this nomogram, obtained through bootstrap validation (resampling = 500), was 0.893 (95% CI, 0.844-0.942). The model demonstrated good calibration, and decision curve analysis showed that when the threshold probability ranged from 7 to 83%, using the nomogram to predict NI provided a net benefit. A novel nomogram has been developed to accurately assess the risk of NI in children under 3 years of age with mTBI and minor SDH, potentially aiding in clinical decision-making.
患有轻度创伤性脑损伤(mTBI)和轻度硬膜下血肿(SDH)的婴幼儿被发现需要神经外科干预(NI)的风险更高。然而,识别需要NI的mTBI和轻度SDH患者的能力仍然有限。本研究旨在开发一种列线图来预测这些患者的NI。使用来自mTBI和轻度SDH患者的人口统计学、临床、影像学和实验室数据建立了预测NI的列线图。采用最小绝对收缩和选择算子(LASSO)回归和最佳子集回归(BSR)方法来识别变量并选择预测因素。使用多变量逻辑回归构建列线图。使用受试者操作特征曲线下面积、校准曲线、Hosmer-Lemeshow检验和决策曲线分析来评估模型的性能。BSR将即刻癫痫发作、贫血和蛛网膜下腔深度确定为显著的预测因素,从而开发出一种列线图。通过自举验证(重采样 = 500)获得的该列线图的AUC为0.893(95% CI,0.844 - 0.942)。该模型显示出良好的校准,决策曲线分析表明,当阈值概率在7%至83%范围内时,使用列线图预测NI可带来净效益。已开发出一种新型列线图,以准确评估3岁以下患有mTBI和轻度SDH儿童的NI风险,可能有助于临床决策。