Belfiore Jacopo, Taddei Riccardo, Biancofiore Giandomenico
Anesthesia and Transplant Intensive Care Unit, Department of Anesthesiology and Intensive Care, University of Pisa, Pisa, Italy.
J Anesth Analg Crit Care. 2025 Apr 3;5(1):17. doi: 10.1186/s44158-025-00241-2.
Catecholamines, essential neurotransmitters and hormones, play a critical role in the body's physiological response to stress and are pivotal in the management of various clinical conditions, particularly in critical care settings. This narrative review delves into the pharmacological properties of catecholamines, including their mechanisms of action, pharmacokinetics, and pharmacodynamics. Key clinical applications of catecholamines, especially in the cardiovascular and immune systems, are highlighted, emphasizing their roles in modulating heart rate, vascular tone, and immune responses during critical conditions such as sepsis and septic shock. Additionally, the review explores catecholamines' immunomodulatory effects and their interactions with other therapeutic agents, such as corticosteroids, in the management of septic shock. Further research is suggested to optimize catecholamine usage and improve patient outcomes in critical care settings.
儿茶酚胺作为重要的神经递质和激素，在机体对压力的生理反应中发挥关键作用，并且在各种临床病症的治疗中起着核心作用，尤其是在重症监护环境中。本叙述性综述深入探讨了儿茶酚胺的药理学特性，包括其作用机制、药代动力学和药效学。重点介绍了儿茶酚胺的关键临床应用，特别是在心血管和免疫系统方面，强调了它们在脓毒症和脓毒性休克等危急情况下调节心率、血管张力和免疫反应的作用。此外，该综述还探讨了儿茶酚胺在脓毒性休克治疗中的免疫调节作用及其与其他治疗药物（如皮质类固醇）的相互作用。建议进一步开展研究，以优化儿茶酚胺的使用并改善重症监护环境中的患者预后。
