Zhang Yu-Xing, Xia Xi-Rui, Guo Si-Yu, Lei Zhen-Xiao, Jiang Hong, Cheng Wan-Min
College of Chemistry, Huazhong Agricultural University, Wuhan 430070, China.
J Org Chem. 2025 Apr 11;90(14):5047-5051. doi: 10.1021/acs.joc.5c00399. Epub 2025 Apr 2.
Simple and atom-economical hydrosulfonylation and arylsulfonylation of alkenes have been developed using sulfinic acid as both the sulfonyl group source and the hydrogen atom donor under light irradiation. These reactions feature catalyst-, oxidant-, and additive-free conditions, offering a highly practical approach for the synthesis of diversely functionalized sulfones. Preliminary mechanistic studies indicate that these reactions proceed via the photoactivation of sulfinic acid to generate a sulfonyl radical, followed by a radical chain process.
在光照条件下，以亚磺酸作为磺酰基源和氢原子供体，开发了简单且原子经济的烯烃氢磺酰化和芳基磺酰化反应。这些反应具有无催化剂、无氧化剂和无添加剂的条件，为合成多种功能化砜提供了一种高度实用的方法。初步机理研究表明，这些反应通过亚磺酸的光活化生成磺酰基自由基，随后进行自由基链反应。
