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小细胞肺癌转移至外耳道:一例报告

Metastasis of Small Cell Lung Cancer to the External Auditory Canal: A Case Report.

作者信息

Ito Toshiyuki, Yoshida Masamichi, Miki Hiroto, Goto Hiroki, Kodama Shuuji, Fujiwara Atsushi, Fujimoto Hajime, Kobayashi Tetsu

机构信息

Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine, Tsu, Mie, Japan.

Department of Respiratory Medicine, Mie Prefectural General Medical Center, Yokkaichi, Mie, Japan.

出版信息

Thorac Cancer. 2025 Apr;16(7):e70059. doi: 10.1111/1759-7714.70059.

Abstract

Patients with lung cancer often develop distant metastases; however, metastasis to the external auditory canal is rare. We report the case of a 77-year-old man who presented with left-sided hearing loss, otalgia, and a red mass in the left external auditory canal. Computed tomography revealed masses in the left external auditory canal, lung, and pancreas. Histopathological analysis confirmed small cell lung cancer, with thyroid transcription factor 1 positivity in multiple lesions, suggesting a primary tumor in lung. Treatment with carboplatin and etoposide led to a reduction in metastatic lesions, including those in the external auditory canal, and improved hearing impairment. This case highlights a rare instance in which chemotherapy improved ear symptoms in a patient with small cell lung cancer metastasis to the external auditory. Written informed consent was obtained from the patient for the publication of this case report and accompanying images.

摘要

肺癌患者常发生远处转移;然而,转移至外耳道的情况罕见。我们报告一例77岁男性病例,该患者出现左侧听力丧失、耳痛以及左侧外耳道肿物。计算机断层扫描显示左侧外耳道、肺部及胰腺有肿物。组织病理学分析确诊为小细胞肺癌,多个病灶甲状腺转录因子1呈阳性,提示原发肿瘤位于肺部。使用卡铂和依托泊苷治疗后,包括外耳道肿物在内的转移病灶缩小,听力障碍得到改善。本病例突出了一个罕见情况,即化疗改善了一名小细胞肺癌转移至外耳道患者的耳部症状。已获得患者的书面知情同意以发表本病例报告及附带图片。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b978/11965702/009d43d3a488/TCA-16-e70059-g005.jpg

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