Liu Jing, Sun Zhenchun, Liu Shaoquan, Lu Yuyun, Guo Chaofan, Cao Jianxin, Wang Xuejiao, Wang Xingwei
Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan, PR China.
Yunnan International Joint Laboratory of Green Food Processing, Kunming University of Science and Technology, Kunming, Yunnan, PR China.
Crit Rev Food Sci Nutr. 2025 Apr 3:1-18. doi: 10.1080/10408398.2025.2480169.
Probiotics play a crucial role in maintaining human health, particularly in intestinal health. However, their application has been hindered by issues related to their stability, survival through the gastrointestinal tract, and effective delivery to target sites. Encapsulating probiotics within liposomes not only protects them from environmental factors such as light, oxygen, and temperature but also shields them from harmful influences like gastric acid and bile. In addition, encapsulation promotes growth, release, and absorption of probiotics in the intestines. This study reviews the characteristics of probiotics and liposomes and their application advantages, and discusses the current state of knowledge of the delivery of probiotics through liposomes. Additionally, the study investigates how the digestive process affects the performance of liposomes and probiotics, focusing on the structural changes that occur in both probiotics and probiotic-loaded liposomes. Finally, the study discusses the challenges and future directions in the field of liposome-delivered probiotics. Liposome delivery of probiotics represents an innovative technology that significantly enhances the stability and bioavailability of probiotics, thereby offering improved protection for individuals' intestinal health. This novel approach creates new possibilities and advantages for probiotics in the realm of intestinal health and is anticipated to receive broader applications in the future.
益生菌在维持人类健康，尤其是肠道健康方面发挥着关键作用。然而，它们的应用受到了与稳定性、在胃肠道中的存活以及有效递送至靶位点等相关问题的阻碍。将益生菌包裹在脂质体内不仅能保护它们免受光、氧和温度等环境因素的影响，还能使它们免受胃酸和胆汁等有害影响。此外，包封促进了益生菌在肠道中的生长、释放和吸收。本研究综述了益生菌和脂质体的特性及其应用优势，并讨论了通过脂质体递送益生菌的现有知识状态。此外，该研究调查了消化过程如何影响脂质体和益生菌的性能，重点关注益生菌和负载益生菌的脂质体中发生的结构变化。最后，该研究讨论了脂质体递送益生菌领域的挑战和未来方向。脂质体递送益生菌是一项创新技术，可显著提高益生菌的稳定性和生物利用度，从而为个体的肠道健康提供更好的保护。这种新方法为益生菌在肠道健康领域创造了新的可能性和优势，并有望在未来得到更广泛的应用。
