Wang Ye, Li Mingyue, Hou Changcheng, Wang Yueyue, Guo Jing, Wang Xurui
School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Health Care Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Pediatr. 2025 Mar 19;13:1520804. doi: 10.3389/fped.2025.1520804. eCollection 2025.
Pediatric pustular psoriasis (PPP) is an autoimmune skin disease that seriously affects the physical and mental health of children. The IL-36RN (Interleukin-36 Receptor Antagonist) gene plays a key role in the pathogenesis of PPP. This review comprehensively elaborates on the research progress of IL-36RN in the context of the pathogenesis and treatment of PPP, covering the basic structure, function, mutation sites and types, and inheritance patterns of the gene and its role in the pathogenesis of PPP. In addition, we discussed the frequency of IL-36RN mutations in patients with different types of PPP and the treatment methods for these patients, aiming to provide a valuable reference for further research and treatment of this disease.
儿童脓疱型银屑病（PPP）是一种严重影响儿童身心健康的自身免疫性皮肤病。白细胞介素-36受体拮抗剂（IL-36RN）基因在PPP的发病机制中起关键作用。本综述全面阐述了IL-36RN在PPP发病机制和治疗方面的研究进展，涵盖了该基因的基本结构、功能、突变位点和类型、遗传模式及其在PPP发病机制中的作用。此外，我们还讨论了不同类型PPP患者中IL-36RN突变的频率以及这些患者的治疗方法，旨在为该疾病的进一步研究和治疗提供有价值的参考。
