Glass R E, Ritchie J K, Lennard-Jones J E, Hawley P R, Todd I P
Dis Colon Rectum. 1985 Aug;28(8):557-61. doi: 10.1007/BF02554140.
There is doubt about the timing of surgery for patients with internal fistulas in Crohn's disease. Although immediate operative intervention for all patients has been advocated, such a policy has not always been followed at St. Mark's Hospital. Between 1971 and 1982, 83 internal fistulas were identified in 59 patients with Crohn's disease. Fifty-nine fistulas arose primarily from the small intestine and involved another segment of the bowel, five were between large bowel and duodenum, and three between areas of large bowel. Sixteen fistulas (ten from ileum and six from large bowel) involved the bladder. Thirty-six patients with 54 fistulas underwent immediate surgical treatment. Fifteen patients with 20 fistulas required surgery later. There was one postoperative death among the 51 patients treated surgically and one late death unrelated to the treatment of the fistula. Of the remaining 49 surgically treated patients, 46 were traced and remain well, six after further surgery. Eight patients with nine fistulas (four involving the bladder) were treated at St. Mark's without operation. One later required surgery elsewhere for an enterocutaneous fistula, but the remaining seven patients are well. This study suggests that the presence of an internal fistula, even if it involves the bladder, is not an absolute indication for immediate surgery and that the severity of the symptoms should dictate the treatment policy.
克罗恩病合并内瘘患者手术时机存在疑问。尽管有人主张对所有患者立即进行手术干预,但圣马克医院并非一直遵循这一政策。1971年至1982年间,在59例克罗恩病患者中发现了83处内瘘。59处瘘主要起源于小肠并累及肠道的另一节段,5处位于大肠与十二指肠之间,3处位于大肠不同部位之间。16处瘘(10处来自回肠,6处来自大肠)累及膀胱。36例有54处瘘的患者接受了立即手术治疗。15例有20处瘘的患者后来需要手术。接受手术治疗的51例患者中有1例术后死亡,1例晚期死亡与瘘的治疗无关。在其余49例接受手术治疗的患者中,46例得到追踪且情况良好,6例接受了进一步手术。8例有9处瘘(4处累及膀胱)的患者在圣马克医院未接受手术治疗。1例后来因肠皮肤瘘在其他地方接受了手术,但其余7例患者情况良好。这项研究表明,即使内瘘累及膀胱,也并非立即手术的绝对指征,症状的严重程度应决定治疗策略。