O'Hagan Edel T, Marschner Simone L, Quintans Desi, Hillis Graham S, Atkins Emily R, Zaman Sarah, Schlaich Markus P, Rodgers Anthony, Chow Clara K
Westmead Applied Research Centre, Faculty of Medicine and Health, The University of Sydney, Australia.
Department of Cardiology, Royal Perth Hospital.
J Hypertens. 2025 Jul 1;43(7):1256-1260. doi: 10.1097/HJH.0000000000004024. Epub 2025 Apr 24.
Women with hypertension are more likely than men to have ineffective treatment where blood pressure (BP) is treated but not controlled. The aim of this study was to investigate whether a quadpill based strategy differs between males and females. A secondary analysis of The Quadruple UltrA-low-dose tReaTment for hypErTension (QUARTET); randomized controlled trial. In this analysis the primary outcome was sex differences in unattended office systolic BP at 12 weeks. The QUARTET study recruited 591 participants (40% female) with mean age 59 (standard deviation 12) years [male 57 (12); female 62 (11)]. Males and females recorded a similar reduction in unattended systolic BP at 12 weeks with no interaction between group allocation and sex [male:mean difference (MD) in mmHg -6.95 (95% CI -9.53 to -4.38), female: MD -6.34 (95% CI -9.50 to -3.18), interaction P = 0.77]. The quadpill strategy was similarly effective in men and women. Initiating BP control with a quadpill in women presents a promising approach to achieving similar BP control levels to men.
高血压女性在接受血压治疗但未得到控制的情况下，比男性更有可能接受无效治疗。本研究的目的是调查基于四联片的治疗策略在男性和女性之间是否存在差异。对高血压四联超低剂量治疗（QUARTET）随机对照试验进行二次分析。在此分析中，主要结局是12周时未监测的诊室收缩压的性别差异。QUARTET研究招募了591名参与者（40%为女性），平均年龄59（标准差12）岁[男性57（12）；女性62（11）]。男性和女性在12周时未监测的收缩压下降幅度相似，组分配与性别之间无相互作用[男性：平均差值（MD），以mmHg计为-6.95（95%置信区间-9.53至-4.38），女性：MD -6.34（95%置信区间-9.50至-3.18），相互作用P = 0.77]。四联片策略在男性和女性中同样有效。对女性采用四联片启动血压控制是实现与男性相似血压控制水平的一种有前景的方法。
