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隐匿性：一例前列腺癌广泛骨转移仅局限于一侧下肢的病例

Below-the-Radar: A Case of Extensive Osseous Metastasis of Prostate Cancer Confined Exclusively to One Lower Limb.

作者信息

Heilinger Jan, Ufton Dominic, Drebber Uta, Schmidt Matthias, Drzezga Alexander

机构信息

Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne.

Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

出版信息

Clin Nucl Med. 2025 May 1;50(5):421-422. doi: 10.1097/RLU.0000000000005756. Epub 2025 Apr 7.

DOI:10.1097/RLU.0000000000005756
PMID:40179294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11967916/
Abstract

Osseous metastases are a common finding in prostate cancer, usually affecting the central skeleton. Metastases in the peripheral skeleton are less frequent but can occur as isolated findings as well. Therefore, imaging protocols limited to the trunk may miss such lesions and extended range (total-body) PSMA-PET/CT may be helpful for comprehensive evaluation, especially when peripheral metastases are suspected, for example, due to clinical symptoms.

摘要

骨转移是前列腺癌的常见表现，通常累及中轴骨骼。外周骨骼转移较少见，但也可单独出现。因此，仅局限于躯干的成像方案可能会遗漏此类病变，而扩展范围（全身）的PSMA-PET/CT可能有助于全面评估，尤其是在怀疑存在外周转移时，例如由于临床症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd8/11967916/c5fa29a2f6d1/rlu-50-421-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd8/11967916/c5fa29a2f6d1/rlu-50-421-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd8/11967916/c5fa29a2f6d1/rlu-50-421-g001.jpg

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本文引用的文献

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Metastatic Prostate Carcinoma to the Ankle Seen on Bone Scintigraphy and Extended Field-of-View PSMA PET/CT.骨闪烁显像及扩展视野PSMA PET/CT检查发现的踝关节转移性前列腺癌
Clin Nucl Med. 2025 Apr 1;50(4):e241-e244. doi: 10.1097/RLU.0000000000005616. Epub 2024 Dec 3.
2
De Novo Metastatic Prostate Cancer Presenting With Atypical Lower-Limb Skeletal Metastases Detected on 68 Ga-PSMA PET/CT.68Ga-PSMA PET/CT检测出的伴有非典型下肢骨骼转移的新发转移性前列腺癌。
Clin Nucl Med. 2024 Jul 1;49(7):e346-e350. doi: 10.1097/RLU.0000000000005239. Epub 2024 Apr 30.
3
PSMA PET/CT: joint EANM procedure guideline/SNMMI procedure standard for prostate cancer imaging 2.0.
PSMA PET/CT：前列腺癌成像 2.0 的 EANM 程序指南/ SNMMI 程序标准联合。
Eur J Nucl Med Mol Imaging. 2023 Apr;50(5):1466-1486. doi: 10.1007/s00259-022-06089-w. Epub 2023 Jan 5.
4
Prostate Cancer Theranostics: From Target Description to Imaging.前列腺癌治疗诊断学：从靶点描述到成像。
PET Clin. 2021 Jul;16(3):383-390. doi: 10.1016/j.cpet.2021.03.003.
5
An F-Labeled PSMA Ligand for PET/CT of Prostate Cancer: First-in-Humans Observational Study and Clinical Experience with F-JK-PSMA-7 During the First Year of Application.一种 F 型 PSMA 配体用于前列腺癌的 PET/CT：F-JK-PSMA-7 在应用的第一年中的首例人体观察性研究和临床经验。
J Nucl Med. 2020 Feb;61(2):202-209. doi: 10.2967/jnumed.119.229542. Epub 2019 Jul 19.
6
Clinical Impact of Lower-Limb Imaging in Ga-PSMA PET/CT for Patients with Prostate Cancer.下肢成像在前列腺癌患者镓-PSMA PET/CT中的临床影响
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7
NKX3.1 and PSMA are sensitive diagnostic markers for prostatic carcinoma in bone metastasis after decalcification of specimens.NKX3.1和前列腺特异性膜抗原是标本脱钙后骨转移前列腺癌的敏感诊断标志物。
Am J Clin Exp Urol. 2018 Oct 20;6(5):182-188. eCollection 2018.
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Prostate cancer metastasis to calcaneus: a solitary lesion at an atypical site, dormant for more than 10 years.前列腺癌转移至跟骨：非典型部位的孤立性病变，隐匿超过10年。
JRSM Open. 2016 Oct 4;7(10):2054270416660934. doi: 10.1177/2054270416660934. eCollection 2016 Oct.
9
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