Zhang Yameng, Oka Yuki
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Curr Opin Neurobiol. 2025 Jun;92:103017. doi: 10.1016/j.conb.2025.103017. Epub 2025 Apr 2.
Maintaining the fluid balance requires complex crosstalk within the neural circuits and endocrine systems through the brain-body axis. Previous research focused on the thirst-driving pathways in the brain. Recent studies have shed more light on the role of postingestive feed-forward modulation mediated by peripheral signals. Advances in technology have unveiled the genetic profiles of the underlying circuits, enabling more precise interventions in future translational research. Despite the prevalence of fluid balance dysregulation in modern life, its health relevance remains underappreciated. In this review, we summarize the recent major findings in the field and describe common fluid-related disorders.
维持体液平衡需要通过脑-体轴在神经回路和内分泌系统内进行复杂的相互作用。以往的研究集中在大脑中驱动口渴的通路。最近的研究进一步揭示了由外周信号介导的摄食后前馈调节的作用。技术的进步揭示了潜在回路的基因特征，为未来的转化研究提供了更精确的干预手段。尽管现代生活中体液平衡失调很普遍，但其与健康的相关性仍未得到充分认识。在这篇综述中，我们总结了该领域最近的主要发现，并描述了常见的与体液相关的疾病。
