发现镁对N-甲基-D-天冬氨酸受体的多方面作用。
Spotting multifaced actions of magnesium on NMDA receptors.
作者信息
Fekete Adam, Wang Lu-Yang
机构信息
Program in Neurosciences & Mental Health, SickKids Research Institute, Toronto, ON M5G 1X8, Canada; Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Program in Neurosciences & Mental Health, SickKids Research Institute, Toronto, ON M5G 1X8, Canada; Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
出版信息
Neuron. 2025 Apr 2;113(7):963-965. doi: 10.1016/j.neuron.2025.03.011.
NMDARs act as coincidence detectors for synaptic plasticity by activity-dependent relief of Mg pore block. In this issue of Neuron, Huang et al. solved the structure of NMDARs to enlighten the fascinating actions of Mg beyond its pore binding..
NMDARs通过依赖活性的Mg孔道阻断解除来充当突触可塑性的巧合探测器。在本期《神经元》杂志中，黄等人解析了NMDARs的结构，以揭示Mg在其孔道结合之外的迷人作用。
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