2024年日本出现对巴洛沙韦敏感性降低的甲型H1N1pdm09流感病毒
Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024.
作者信息
Takashita Emi, Morita Hiroko, Nagata Shiho, Fujisaki Seiichiro, Miura Hideka, Ikeda Tatsuya, Komabayashi Kenichi, Sasaki Mika, Matoba Yohei, Takahashi Tomoko, Ogawa Naomi, Mizuta Katsumi, Ito Sueshi, Kishida Noriko, Nakamura Kazuya, Shirakura Masayuki, Watanabe Shinji, Hasegawa Hideki
出版信息
Emerg Infect Dis. 2025 May;31(5):1019-1023. doi: 10.3201/eid3105.241123. Epub 2025 Apr 3.
Influenza A(H1N1)pdm09 virus carrying an I38N substitution was detected in an untreated teenager in Japan. The I38N mutant virus exhibited reduced susceptibility to baloxavir but remained susceptible to neuraminidase inhibitors and showed reduced growth capability. Monitoring antiviral drug susceptibility of influenza viruses is necessary to aid public health planning and clinical recommendations.
在日本一名未经治疗的青少年体内检测到携带I38N替换的甲型H1N1pdm09流感病毒。I38N突变病毒对巴洛沙韦的敏感性降低，但对神经氨酸酶抑制剂仍敏感，且生长能力降低。监测流感病毒的抗病毒药物敏感性对于协助公共卫生规划和临床建议很有必要。
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