Kobayashi M, Miyakoda G, Nakamura T, Ohizumi Y
Eur J Pharmacol. 1985 Apr 23;111(1):121-3. doi: 10.1016/0014-2999(85)90120-7.
Maitotoxin (MTX) (0.1-10 ng/ml) caused an increase in the degree and the rate of contraction and subsequent arrhythmogenic actions in rat myocardial cells. These effects of MTX were inhibited by verapamil and were abolished by Ca2+-free medium. The MTX-induced effects on cardiac myocytes were enhanced by increasing the Ca2+ concentration. These results suggest that MTX elevates the permeability of cardiac muscle membrane to Ca2+ to increase the intracellular Ca2+ concentration, and thus induces excitatory effects.
刺尾鱼毒素（MTX）（0.1 - 10纳克/毫升）可使大鼠心肌细胞的收缩程度和速率增加，并随后引发致心律失常作用。MTX的这些作用可被维拉帕米抑制，且在无钙培养基中消失。通过增加钙离子浓度可增强MTX对心肌细胞的作用。这些结果表明，MTX提高了心肌细胞膜对钙离子的通透性，以增加细胞内钙离子浓度，从而诱导兴奋作用。
