Suresh M S, Nelson S H, Nelson T E, Steinsland O S
Eur J Pharmacol. 1985 Jun 19;112(3):387-91. doi: 10.1016/0014-2999(85)90785-x.
The effect of verapamil on the contractile response to norepinephrine in isolated, suffused uterine arteries from pregnant and nonpregnant humans was investigated. The arteries, obtained after hysterectomy, were dissected free from surrounding tissue and arterial rings were prepared and mounted in tissue chambers filled with Krebs-bicarbonate solution. Isometric tension was recorded. There was no significant difference between arteries from pregnant patients and arteries from nonpregnant patients when maximal contractile response and sensitivity to norepinephrine were compared. At concentrations of 0.3 and 3 microM, verapamil attenuated the response to norepinephrine in uterine arteries from both pregnant and nonpregnant patients. However, verapamil was significantly more potent in blocking the response to norepinephrine in arteries from pregnant patients.
研究了维拉帕米对来自孕妇和非孕妇的离体灌注子宫动脉中去甲肾上腺素收缩反应的影响。子宫切除术后获取的动脉，从周围组织中分离出来，制备动脉环并安装在充满 Krebs-碳酸氢盐溶液的组织浴槽中。记录等长张力。比较最大收缩反应和对去甲肾上腺素的敏感性时，孕妇动脉和非孕妇动脉之间没有显著差异。在0.3和3微摩尔浓度下，维拉帕米减弱了孕妇和非孕妇子宫动脉对去甲肾上腺素的反应。然而，维拉帕米在阻断孕妇动脉对去甲肾上腺素的反应方面显著更有效。
