Sterman A B, Delannoy M R
Exp Neurol. 1985 Aug;89(2):408-19. doi: 10.1016/0014-4886(85)90100-1.
To compare the evolution of cell body responses to two different types of axonal injuries--sciatic nerve crush (axotomy) and chronic 2,5-hexanedione-induced neuropathy--we studied rat lumbar dorsal root ganglion neurons with light microscopy and morphometry. Compared with control neurons, axotomized cells showed early (1 day) increases in the frequencies of two responses, nuclear eccentricity and Nissl body displacement, and later (4 day) increases in average satellite cell nuclei and decreases in perikaryal diameters. In toxin-induced axonal degeneration, there were similar patterns of defined alterations, although the evolution progressed over weeks and the response magnitudes were smaller. We conclude that the two experimental conditions show basic morphologic similarities, implying cell body reorganization in toxic axonopathy may be a response to axonal dysfunction or degeneration.
为比较细胞体对两种不同类型轴突损伤（坐骨神经挤压伤（轴突切断术）和慢性2,5 -己二酮诱导的神经病变）的反应演变，我们用光学显微镜和形态测量法研究了大鼠腰段背根神经节神经元。与对照神经元相比，轴突切断的细胞在两种反应（核偏心率和尼氏体移位）的频率上早期（1天）增加，后期（4天）卫星细胞核平均数增加，而核周直径减小。在毒素诱导的轴突变性中，也有类似的明确改变模式，尽管演变过程持续数周且反应幅度较小。我们得出结论，这两种实验条件显示出基本的形态学相似性，这意味着在中毒性轴突病中细胞体重组可能是对轴突功能障碍或变性的一种反应。
