2024年至2025年，英国无家可归的药物使用人群中出现的毒素阴性暴发性感染性心内膜炎。
Fulminant infective endocarditis with toxin-negative in people with substance use experiencing homelessness, England, 2024 to 2025.
作者信息
Patel Tara, Anwar Tasnim, Mavrogiorgou Eleni, Utjesanovic Natasa, Aryee Anna, Litt David J, D'Aeth Joshua C, Primus Christopher, Das Satya, Karogiannis Nikolaos, Paranthaman Karthik, Amirthalingam Gayatri, Cordery Rebecca
机构信息
UK Health Security Agency, London, United Kingdom.
These authors contributed equally to this work and share first authorship.
出版信息
Euro Surveill. 2025 Apr;30(13). doi: 10.2807/1560-7917.ES.2025.30.13.2500148.
Between July 2024 and January 2025, five male patients in their early 20s to early 50s were confirmed with infective endocarditis associated with non-toxigenic in England. Three were known to have experienced homelessness. All five used non-intravenous recreational drugs. Disease progression was rapid, four patients required surgical intervention, one died. Whole-genome sequencing and multilocus sequence type (MLST) analysis identified four individuals as ST559. Clinicians and substance use services have been alerted and enhanced surveillance implemented. A prevalence study is planned.
在2024年7月至2025年1月期间，英国有5名年龄在20岁出头至50岁出头的男性患者被确诊患有与非产毒型相关的感染性心内膜炎。其中3人有过无家可归的经历。所有5人都使用非静脉注射的消遣性药物。疾病进展迅速，4名患者需要手术干预，1人死亡。全基因组测序和多位点序列分型（MLST）分析确定4人为ST559型。已向临床医生和物质使用服务机构发出警报并实施了强化监测。计划开展一项患病率研究。
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