遗传学证据表明甲状腺功能亢进与膝关节骨关节炎有关。
Genetic evidence links hyperthyroidism to knee osteoarthritis.
作者信息
Xu Tianli, Shen Limin, Cao Xiaojun, Song Jincheng, Tang Mengjie, Yue Chaoyan
机构信息
Department of Orthopedics, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou, 215123, Jiangsu, China.
Department of Endocrinology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou, 215123, Jiangsu, China.
出版信息
Hormones (Athens). 2025 Apr 4. doi: 10.1007/s42000-025-00648-0.
PURPOSE
The causal relationship between hyperthyroidism and knee osteoarthritis (KOA) remains to date unknown. We aimed to examine the potential causal relationship between hyperthyroidism status and the risk of developing KOA via a bidirectional two-sample Mendelian randomization (MR) approach.
METHODS
Single-nucleotide polymorphism (SNP) data related to hyperthyroidism and KOA were obtained from a genome-wide association study (GWAS) in Europe. KOA was used as the outcome variable and hyperthyroidism was used as the exposure factor. The inverse-variance weighted (IVW) method served as the primary analytic tool and heterogeneity and pleiotropy were evaluated via sensitivity analysis.
RESULTS
The IVW method indicated that hyperthyroidism status has a causative influence on the risk of developing KOA [OR, 1.046; 95% confidence interval (CI), 1.013-1.080; P = 0.006]. No significant reverse causality was detected. Sensitivity analyses validated the robustness of these findings.
CONCLUSIONS
Hyperthyroidism status can causally increase the risk of developing KOA. This result indicated that the risk of developing KOA may be decreased by controlling hyperthyroidism.
目的
甲状腺功能亢进症与膝关节骨关节炎（KOA）之间的因果关系至今仍不清楚。我们旨在通过双向双样本孟德尔随机化（MR）方法研究甲状腺功能亢进状态与患KOA风险之间的潜在因果关系。
方法
与甲状腺功能亢进症和KOA相关的单核苷酸多态性（SNP）数据来自欧洲的一项全基因组关联研究（GWAS）。将KOA用作结果变量，将甲状腺功能亢进症用作暴露因素。逆方差加权（IVW）方法作为主要分析工具，并通过敏感性分析评估异质性和多效性。
结果
IVW方法表明，甲状腺功能亢进状态对患KOA的风险有因果影响[比值比（OR），1.046；95%置信区间（CI），1.013 - 1.080；P = 0.006]。未检测到明显的反向因果关系。敏感性分析验证了这些发现的稳健性。
结论
甲状腺功能亢进状态可因果性地增加患KOA的风险。这一结果表明，通过控制甲状腺功能亢进症，可能会降低患KOA的风险。
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