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前列腺癌放疗中SpaceOAR水凝胶并发症:图文综述

SpaceOAR hydrogel complications in prostate cancer radiotherapy: a pictorial review.

作者信息

Pohl Maximilian, Nakrour Nabih, Aswani Yashant, Ghosh Soumyadeep, Pohl Klara, Elshikh Abdelrahman, Yatin Mankan, Cochran Rory L, Fuchsjaeger Michael, Harisinghani Mukesh

机构信息

Massachusetts General Hospital, Harvard Medical School, Boston, United States.

Medical University of Graz, Graz, Austria.

出版信息

Abdom Radiol (NY). 2025 Apr 5. doi: 10.1007/s00261-025-04922-y.

DOI:10.1007/s00261-025-04922-y
PMID:40186647
Abstract

Since its approval by the United States Food and Drug Administration (FDA), the rectal hydrogel spacer system SpaceOAR (SpaceOAR™ and Space-OAR Vue™, Boston Scientific Corporation, Marlborough, Massachusetts, United States) has become widely adopted in radiation therapy protocols for prostate cancer patients. The biodegradable hydrogel creates a temporary space between the prostate and rectum, thereby effectively reducing the radiation exposure to the anterior rectal wall. While the system is generally safe, potential complications can occur and should be recognized by radiologists. This pictorial review aims to familiarize radiologists with imaging features of SpaceOAR-related complications to ensure accurate diagnosis and reporting.

摘要

自美国食品药品监督管理局(FDA)批准以来,直肠水凝胶间隔系统SpaceOAR(SpaceOAR™和Space - OAR Vue™,美国马萨诸塞州马尔伯勒市波士顿科学公司)已在前列腺癌患者的放射治疗方案中广泛应用。这种可生物降解的水凝胶在前列腺和直肠之间形成一个临时空间,从而有效减少直肠前壁的辐射暴露。虽然该系统总体安全,但仍可能发生潜在并发症,放射科医生应予以识别。本图像综述旨在使放射科医生熟悉与SpaceOAR相关并发症的影像特征,以确保准确诊断和报告。

相似文献

1
SpaceOAR hydrogel complications in prostate cancer radiotherapy: a pictorial review.前列腺癌放疗中SpaceOAR水凝胶并发症:图文综述
Abdom Radiol (NY). 2025 Apr 5. doi: 10.1007/s00261-025-04922-y.
2
Application of Hydrogel Spacer SpaceOAR Vue for Prostate Radiotherapy.水凝胶间隔物 SpaceOAR Vue 在前列腺放疗中的应用。
Tomography. 2022 Oct 27;8(6):2648-2661. doi: 10.3390/tomography8060221.
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SpaceOAR hydrogel complications in prostate cancer.前列腺癌中 SpaceOAR 水凝胶的并发症。
Br J Radiol. 2023 Dec;96(1152):20230717. doi: 10.1259/bjr.20230717. Epub 2023 Oct 24.
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SpaceOAR hydrogel spacer injection prior to stereotactic body radiation therapy for men with localized prostate cancer: A systematic review.局部前列腺癌患者立体定向体部放射治疗前注射 SpaceOAR 水凝胶 spacer:系统评价。
Medicine (Baltimore). 2021 Dec 10;100(49):e28111. doi: 10.1097/MD.0000000000028111.
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Major Complications and Adverse Events Related to the Injection of the SpaceOAR Hydrogel System Before Radiotherapy for Prostate Cancer: Review of the Manufacturer and User Facility Device Experience Database.前列腺癌放疗前注射 SpaceOAR 水凝胶系统的主要并发症和不良事件:制造商和用户设施设备经验数据库的回顾。
J Endourol. 2019 Oct;33(10):868-871. doi: 10.1089/end.2019.0431. Epub 2019 Sep 27.
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The case of the missing spacer!缺失的间隔物事件!
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Rectal complications following SpaceOAR insertion after prior pelvic radiation.既往盆腔放疗后插入SpaceOAR后的直肠并发症。
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Improved rectal dosimetry with the use of SpaceOAR during high-dose-rate brachytherapy.在高剂量率近距离放射治疗期间使用SpaceOAR改善直肠剂量测定法。
Brachytherapy. 2018 Mar-Apr;17(2):259-264. doi: 10.1016/j.brachy.2017.10.014. Epub 2017 Dec 2.
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The use of hyperbaric oxygen to treat actinic rectal fistula after SpaceOAR use and radiotherapy for prostate cancer: a case report.高压氧治疗前列腺癌 SpaceOAR 应用及放疗后放射性直肠瘘 1 例报告
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SpaceOAR hydrogel distribution and early complications in patients undergoing radiation therapy for prostate cancer.前列腺癌患者接受放射治疗时 SpaceOAR 水凝胶的分布和早期并发症。
Br J Radiol. 2023 Dec;96(1152):20220947. doi: 10.1259/bjr.20220947. Epub 2023 Oct 24.

本文引用的文献

1
Complications and Influential Perioperative Factors Associated with SpaceOAR Hydrogel Placement.与SpaceOAR水凝胶置入相关的并发症及围手术期影响因素
Adv Urol. 2024 Sep 3;2024:3439727. doi: 10.1155/2024/3439727. eCollection 2024.
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Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.2022 年全球癌症统计数据:全球 185 个国家和地区 36 种癌症的发病率和死亡率全球估计数。
CA Cancer J Clin. 2024 May-Jun;74(3):229-263. doi: 10.3322/caac.21834. Epub 2024 Apr 4.
3
Major Complications and Adverse Events Related to Use of SpaceOAR Hydrogel for Prostate Cancer Radiotherapy.
用于前列腺癌放射治疗的 SpaceOAR 水凝胶相关的主要并发症和不良事件。
Urology. 2024 Jun;188:94-100. doi: 10.1016/j.urology.2023.12.034. Epub 2024 Mar 6.
4
SpaceOAR hydrogel complications in prostate cancer.前列腺癌中 SpaceOAR 水凝胶的并发症。
Br J Radiol. 2023 Dec;96(1152):20230717. doi: 10.1259/bjr.20230717. Epub 2023 Oct 24.
5
Safety of hydrogel spacers for rectal wall protection in patients with prostate cancer: A retrospective analysis of 200 consecutive cases.水凝胶间隔物对前列腺癌患者直肠壁保护的安全性:200例连续病例的回顾性分析
Int J Urol. 2023 Apr;30(4):401-407. doi: 10.1111/iju.15140. Epub 2023 Jan 18.
6
Creation of a protective space between the rectum and prostate prior to prostate radiotherapy using a hydrogel spacer.在前列腺放射治疗前使用水凝胶间隔物在直肠和前列腺之间创建保护空间。
Clin Radiol. 2022 Mar;77(3):e195-e200. doi: 10.1016/j.crad.2021.12.004. Epub 2021 Dec 31.
7
Patient Reported Quality of Life Outcomes After Definitive Radiation Therapy With Absorbable Spacer Hydrogel for Prostate Cancer.使用可吸收间隔水凝胶对前列腺癌进行根治性放射治疗后患者报告的生活质量结果
Adv Radiat Oncol. 2021 Jul 15;6(6):100755. doi: 10.1016/j.adro.2021.100755. eCollection 2021 Nov-Dec.
8
SpaceOAR Hydrogel Spacer for Reducing Radiation Toxicity During Radiotherapy for Prostate Cancer. A Systematic Review.前列腺癌放疗中应用 SpaceOAR Hydrogel 隔离剂以减少放射性毒性:系统评价
Urology. 2021 Oct;156:e74-e85. doi: 10.1016/j.urology.2021.05.013. Epub 2021 May 23.
9
Dosimetric and clinical outcomes of SpaceOAR in men undergoing external beam radiation therapy for localized prostate cancer: A systematic review.SpaceOAR在接受局部前列腺癌外照射放疗的男性中的剂量学和临床结果:一项系统评价。
J Med Imaging Radiat Oncol. 2021 Jun;65(3):384-397. doi: 10.1111/1754-9485.13179. Epub 2021 Apr 14.
10
Rectourethral fistula following SpaceOAR gel placement for prostate cancer radiotherapy: A rare complication.用于前列腺癌放疗的SpaceOAR凝胶置入术后直肠尿道瘘:一种罕见的并发症。
Urol Case Rep. 2020 Dec 1;35:101516. doi: 10.1016/j.eucr.2020.101516. eCollection 2021 Mar.