Xuejiao Yang, Shuo Yu, Xian Yang, Lingling Wu
Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Lasers Med Sci. 2025 Apr 5;40(1):176. doi: 10.1007/s10103-025-04372-4.
To evaluate the efficacy of selective laser trabeculoplasty (SLT) on intraocular pressure (IOP) for the normal tension glaucoma (NTG) in Chinese. Consecutive patients with NTG treated with monocular SLT for eye with higher IOP were enrolled. IOP was evaluated for each patient before SLT, 1 h, 1 week, 1, 3, 6 months, 1 and 2 years after treatment. The treatment success was defined as IOP reduction from the preoperative IOP by 20%. Thirty-two patients with 18.47 ± 9.98 months follow-up were eligible for analyses. The mean IOP reduction after SLT were 2.80 mmHg (15.76%), 2.60 mmHg (15.57%), 2.51 mmHg (15.06%), 3.42 mmHg (20.51%), and 2.41 mmHg (14.46%) at 1, 3, 6 months, 1 and 2 years post-SLT respectively for the treated eyes. While there were 1.39 mmHg (8.94%) and 2.13 mmHg (13.71%) IOP reduction in the fellow eyes at 1 month and 1 year post-SLT respectively. There was positive correlation of IOP reduction between SLT eyes and the fellow eyes (r = 0.6503, P < 0.0001). The absolute success rate for SLT treated eyes mounted to 41.38% at 6 months and decreased to 18.18% at 2 years post-SLT. The success was associated with the number of medicines, pre-IOP and the IOP reduction at 1 and 3 months after SLT. SLT has an effect on lowering IOP for NTG patients in Chinese in both SLT eyes and the follow eyes with insufficient efficacy of anti-glaucoma medications, although the effect was not sustained with a longer follow-up.
评估选择性激光小梁成形术（SLT）对中国正常眼压性青光眼（NTG）患者眼压（IOP）的疗效。纳入连续的NTG患者，对眼压较高的眼进行单眼SLT治疗。在SLT治疗前、治疗后1小时、1周、1、3、6个月、1年和2年对每位患者的眼压进行评估。治疗成功定义为眼压较术前降低20%。32例患者随访18.47±9.98个月，符合分析条件。SLT治疗眼在SLT后1、3、6个月、1年和2年时眼压平均降低分别为2.80 mmHg（15.76%）、2.60 mmHg（15.57%）、2.51 mmHg（15.06%）、3.42 mmHg（20.51%）和2.41 mmHg（14.46%）。而在SLT后1个月和1年时，对侧眼眼压分别降低1.39 mmHg（8.94%）和2.13 mmHg（13.71%）。SLT治疗眼与对侧眼的眼压降低呈正相关（r = 0.6503，P < 0.0001）。SLT治疗眼在6个月时的绝对成功率升至41.38%，在SLT后2年降至18.18%。治疗成功与用药数量、术前眼压以及SLT后1个月和3个月时的眼压降低有关。对于使用抗青光眼药物疗效不佳的中国NTG患者，SLT对降低SLT治疗眼及对侧眼的眼压均有作用，尽管随访时间延长后效果未持续。
