[C]ER176可对不同TSPO基因型的脑部炎症进行成像，并与tau蛋白共定位。
[C]ER176 images brain inflammation across TSPO genotypes and colocalizes with tau.
作者信息
Chaney Aisling M, Gordon Brian A
机构信息
Department of Radiology, Washington University, St. Louis, MO, USA.
Department of Radiology, Washington University, St. Louis, MO, USA.
出版信息
Trends Neurosci. 2025 May;48(5):315-316. doi: 10.1016/j.tins.2025.03.005. Epub 2025 Apr 4.
Accurately measuring brain inflammation in Alzheimer's disease (AD) is crucial due to the role of inflammatory processes in neurodegeneration. In a recent study, Appleton, Finn, et al. used [C]ER176, a novel translocator protein 18 kDa (TSPO)-positron emission tomography (PET) tracer overcoming genotype-related binding issues, to show increased inflammation in early-onset AD, with patterns aligning more closely with tau pathology than amyloid deposition or atrophy.
由于炎症过程在神经退行性变中的作用，准确测量阿尔茨海默病（AD）中的脑炎症至关重要。在最近的一项研究中，阿普尔顿、芬恩等人使用了[C]ER176，一种新型的18 kDa转运蛋白（TSPO）-正电子发射断层扫描（PET）示踪剂，该示踪剂克服了与基因型相关的结合问题，以显示早发性AD中炎症增加，其模式与tau病理的相关性比淀粉样蛋白沉积或萎缩更为密切。
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