Shah Amy S, Kelsey Megan M, Wolf Risa M, Nadeau Kristen J
Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Department of Pediatrics, Division of Endocrinology, Cincinnati, OH, USA.
Section of Endocrinology, Department of Pediatrics, School of Medicine and Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Trends Endocrinol Metab. 2025 Apr 4. doi: 10.1016/j.tem.2025.03.003.
Youth-onset type 2 diabetes (YO-T2D) is an urgent public health challenge that demands immediate and innovative action. The devastating trajectory of this disease - from rapid β-cell decline to early complications and poor responses to medications - compels us to rethink our approach. Here, we argue that by investing in targeted research to unravel the unique mechanisms of this condition, ensuring equitable access to cutting-edge clinical trials, and building clinical care models tailored specifically for youth, we can rewrite the narrative for these at-risk youth.
青少年2型糖尿病（YO-T2D）是一项紧迫的公共卫生挑战，需要立即采取创新行动。这种疾病的发展轨迹极具破坏性——从β细胞迅速衰退到早期并发症以及对药物反应不佳——促使我们重新思考应对方法。在此，我们认为，通过投入针对性研究以揭示这种疾病的独特机制，确保公平参与前沿临床试验的机会，并建立专门为青少年量身定制的临床护理模式，我们能够改写这些高危青少年的命运。
