Kim Haejung, Park Goeun, Kim Myoung Kyoung, Oh Young Lyun, Kim Tae Hyuk, Shin Jung Hee, Hahn Soo Yeon
Department of Radiology and Center for Imaging Science, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.
Biomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, South Korea.
Sci Rep. 2025 Apr 5;15(1):11736. doi: 10.1038/s41598-025-96774-1.
TERT promoter mutation is associated with poor prognosis in differentiated thyroid carcinoma, with US features varying by mutation status. However, this correlation in anaplastic thyroid carcinoma (ATC) is understudied. We investigated the association between clinicopathological characteristics and US features of ATC with TERT mutation status and prognosis. From November 1994 to May 2022, 58 ATC nodules from 58 patients were analyzed. Two radiologists retrospectively reviewed US features based on the revised K-TIRADS and ACR-TIRADS. Of all 58 ATC nodules, 32 nodules were tested for TERT promoter mutation and detected in 11. TERT promoter-mutated ATC was larger than TERT wild-type ATC (p = 0.032); however, no other differences were observed. ATC with survival period of less than 12 months were more likely to have lymph node metastasis (p = 0.012) or distant metastasis at diagnosis (p < 0.001), larger size on US (p = 0.005), and suspicion for gross extrathyroidal extension on US (p = 0.04) compared to ATC with survival period of 12 months or more. Advanced disease at diagnosis was a critical factor associated with 1-year survival in patients with ATC, whereas the TERT promoter mutation status was not.
端粒酶逆转录酶（TERT）启动子突变与分化型甲状腺癌的不良预后相关，超声特征因突变状态而异。然而，间变性甲状腺癌（ATC）中的这种相关性研究较少。我们研究了ATC的临床病理特征、超声特征与TERT突变状态及预后之间的关联。1994年11月至2022年5月，对58例患者的58个ATC结节进行了分析。两名放射科医生根据修订后的K-TIRADS和ACR-TIRADS回顾性评估了超声特征。在所有58个ATC结节中，对32个结节进行了TERT启动子突变检测，其中11个检测到突变。TERT启动子突变的ATC比TERT野生型ATC更大（p = 0.032）；然而，未观察到其他差异。与生存期≥12个月的ATC相比，生存期<12个月的ATC在诊断时更可能发生淋巴结转移（p = 0.012）或远处转移（p < 0.001），超声显示的肿瘤更大（p = 0.005），且超声怀疑有甲状腺外大体侵犯（p = 0.04）。诊断时的晚期疾病是ATC患者1年生存的关键相关因素，而TERT启动子突变状态并非如此。
