Shang Wenyu, Geng Xiaofei, Sun Xitong, Fan Xinbiao, Li Aolin, Zhang Chi, Kang Yuxin, Liang Yongchun, Zhang Junping
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300000, China.
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300000, China.
Int J Biol Macromol. 2025 May;309(Pt 2):142865. doi: 10.1016/j.ijbiomac.2025.142865. Epub 2025 Apr 4.
Diabetic cardiomyopathy (DCM) is a leading cause of heart failure (HF) among individuals with diabetes, presenting a significant medical challenge due to its complex pathophysiology and the lack of targeted therapies. Pyroptosis, a pro-inflammatory form of programmed cell death (PCD), is the predominant mode of cell death in the primary resident cells involved in DCM. It has been reported to be critical in DCM's onset, progression, and pathogenesis. Non-coding RNAs (ncRNAs), diverse transcripts lacking protein-coding potential, are essential for cellular physiology and the progression of various diseases. Increasing evidence indicates that ncRNAs are pivotal in the pathogenesis of DCM by regulating pyroptosis. This observation suggests that targeting the regulation of pyroptosis by ncRNAs may offer a novel therapeutic approach for DCM. However, a comprehensive review of this topic is currently lacking. Our objective is to elucidate the regulatory role of ncRNAs in pyroptosis associated with DCM and to elucidate the relationships among these factors. Additionally, we explored how ncRNAs influence pyroptosis and contribute to the pathophysiology of DCM. By doing so, we aim to identify new research targets for the clinical diagnosis and treatment of DCM.
糖尿病性心肌病（DCM）是糖尿病患者心力衰竭（HF）的主要原因，由于其复杂的病理生理学和缺乏靶向治疗方法，构成了重大的医学挑战。细胞焦亡是程序性细胞死亡（PCD）的一种促炎形式，是DCM中主要的驻留细胞的主要细胞死亡模式。据报道，它在DCM的发生、发展和发病机制中起关键作用。非编码RNA（ncRNAs）是缺乏蛋白质编码潜力的多种转录本，对细胞生理学和各种疾病的进展至关重要。越来越多的证据表明，ncRNAs通过调节细胞焦亡在DCM的发病机制中起关键作用。这一观察结果表明，靶向ncRNAs对细胞焦亡的调节可能为DCM提供一种新的治疗方法。然而，目前缺乏对该主题的全面综述。我们的目的是阐明ncRNAs在与DCM相关的细胞焦亡中的调节作用，并阐明这些因素之间的关系。此外，我们探讨了ncRNAs如何影响细胞焦亡并促进DCM的病理生理学。通过这样做，我们旨在为DCM的临床诊断和治疗确定新的研究靶点。
