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1例用奥克拉替尼治疗的犬舌淋巴瘤病例。

A case of lingual lymphoma in a dog treated with oclacitinib.

作者信息

Nishimori Shohei, Okano Kumiko, Nibe Kazumi, Igase Masaya, Mizuno Takuya

机构信息

Jiyugaoka Animal Clinic, Tokyo, Japan.

Japan Veterinary Advanced Medical Center, Kawasaki Main Hospital, Kanagawa, Japan.

出版信息

J Vet Med Sci. 2025 May 15;87(5):541-545. doi: 10.1292/jvms.24-0432. Epub 2025 Apr 5.

Abstract

Lingual canine T-zone lymphoma (TZL) is a rare form of extranodal canine lymphoma. Seven-years and 5 months old, spayed female toy poodle presented with a red swollen mass on the tongue. A punch biopsy of the lesion was conducted, followed by histopathological and immunohistochemical analyses. Despite the absence of a lymph node excisional biopsy, the case was diagnosed as canine lingual TZL. Although there is no established treatment for lingual TZL, treatment often follows TZL protocols. In this case, the tongue lesion improved after the administration of oclacitinib, a drug approved for canine atopic dermatitis. We present this case due to its successful management with oclacitinib, without the use of conventional anticancer therapy.

摘要

舌部犬T细胞区淋巴瘤(TZL)是一种罕见的结外犬淋巴瘤。一只7岁5个月大、已绝育的雌性玩具贵宾犬出现舌部红色肿胀肿物。对病变进行了穿刺活检,随后进行了组织病理学和免疫组织化学分析。尽管未进行淋巴结切除活检,但该病例被诊断为犬舌部TZL。虽然舌部TZL尚无既定的治疗方法,但治疗通常遵循TZL方案。在本病例中,给予已获批准用于犬特应性皮炎的奥克拉替尼后,舌部病变有所改善。我们报告此病例是因为其使用奥克拉替尼成功治疗,未使用传统抗癌疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ab/12150885/ff64e8ff240c/jvms-87-5-541-g001.jpg

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