Labeeuw M, Cabanne J F
Int J Clin Pharmacol Ther Toxicol. 1985 Jun;23(6):316-9.
Seven patients with advanced renal failure, six of whom were dialysed, received a cation exchange resin in the calcium cycle because of severe hyperkalemia, together with their usual preventive treatment of renal osteodystrophy, including 25 hydroxycholecalciferol. Hypercalcemia developed in four subjects within less than thirty days and disappeared within four days following the withdrawal of the resin. Patients who exhibited hypercalcemia had higher calcium intake, lower predialysis blood calcium and higher PTH values before introduction of the treatment. Three of the four hypercalcemic patients were diabetics. It is therefore advised to frequently monitor blood calcium when using calcium exchange resin in patients treated with vitamin D analogs.
7例晚期肾衰竭患者（其中6例接受透析治疗）因严重高钾血症接受了钙循环中的阳离子交换树脂治疗，同时接受了常规的肾性骨营养不良预防性治疗，包括使用25-羟胆钙化醇。4名患者在不到30天内出现高钙血症，在停用树脂后4天内消失。出现高钙血症的患者在开始治疗前钙摄入量较高、透析前血钙较低且甲状旁腺激素（PTH）值较高。4名高钙血症患者中有3名是糖尿病患者。因此，建议在用维生素D类似物治疗的患者中使用钙交换树脂时频繁监测血钙。
