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[小肾肿瘤的部分肾切除术与局部治疗]

[Partial Nephrectomy and Focal Therapy in Small Renal Tumors].

作者信息

Matsui Yoshiyuki

机构信息

Dept. of Urology, National Cancer Center Hospital.

出版信息

Gan To Kagaku Ryoho. 2025 Mar;52(3):205-209.

Abstract

With the increasing use of robot-assisted surgery, partial nephrectomy is recommended for small renal tumors(T1a)with a tumor size of 4 cm or less and is now considered a standard treatment. However, with the rise in incidental detection of small renal tumors during routine screenings, especially in elderly patients or those with comorbidities who may hesitate to undergo general anesthesia, there is a growing need for alternative treatments such as focal therapy to partial nephrectomy. The main methods of focal therapy include ablation techniques such as cryotherapy and radiofrequency ablation. Recently, stereotactic body radiotherapy has also been approved for insurance coverage, emerging as a minimally invasive option for renal cell carcinoma with a tumor size of 5 cm or less. Additionally, although not a focal therapy, active surveillance is also considered an effective option for very small renal tumors. Among these various treatment options, shared decision making between patients and healthcare providers, considering factors such as tumor characteristics and patient-specific conditions, is considered crucial in determining the appropriate treatment strategy for small renal tumors. In the absence of large-scale prospective comparative trials on partial nephrectomy, ablation therapy, stereotactic radiotherapy, and active surveillance, this paper provides an overview of the characteristics of each treatment modality and their respective outcomes and discusses the future perspectives in the treatment of small renal tumors.

摘要

随着机器人辅助手术的使用日益增加,对于肿瘤大小为4厘米或更小的小肾肿瘤(T1a),推荐行部分肾切除术,目前这被视为标准治疗方法。然而,随着在常规筛查中偶然发现的小肾肿瘤增多,尤其是在老年患者或那些可能对全身麻醉有所顾虑的合并症患者中,对替代部分肾切除术的治疗方法(如局部治疗)的需求日益增长。局部治疗的主要方法包括冷冻疗法和射频消融等消融技术。最近,立体定向体部放疗也已获批纳入医保范围,成为肿瘤大小为5厘米或更小的肾细胞癌的一种微创选择。此外,尽管主动监测并非局部治疗,但对于非常小的肾肿瘤也被视为一种有效选择。在这些各种治疗选择中,患者与医疗服务提供者之间的共同决策,考虑肿瘤特征和患者具体情况等因素,在确定小肾肿瘤的适当治疗策略方面被认为至关重要。在缺乏关于部分肾切除术、消融治疗、立体定向放疗和主动监测的大规模前瞻性比较试验的情况下,本文概述了每种治疗方式的特点及其各自的结果,并讨论了小肾肿瘤治疗的未来前景。

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