Vobecky J S, Vobecky J, Shapcott D, Demers P P, Blanchard R, Fisch C
Int J Vitam Nutr Res. 1985;55(2):205-16.
In infancy an adequate intake of vitamins, either from natural sources or as supplements, is of the utmost importance. The vitamin status of 325 infants was studied with regard to their food intake, vitamin supplementation and health from birth to the third birthday. Only data on vitamins A, C, E and folic acid are presented here. The proportion of bottle-fed infants having a serum level of vitamin C less than 0.30 mg/dl was 4.0 times (P less than 0.002), and of vitamin E less than 0.35 mg/dl was 2.2 times (P less than 0.05) higher than that of breast-fed infants. The proportion of infants with folate level less than 6.0 ng/ml was identical in both groups. No infant was observed with a vitamin A serum level less than 40 mcg/dl. The daily food intake of vitamin C less than 80% of RNI was found n 40% of infants at 6 months, in 10% at 12, and in none at 18 months and afterwards. Vitamin A followed a similar trend. 95% of infants had vitamin E and 75% had folate intake less than 80% RNI. Obviously the mean serum levels of vitamins A and C were significantly higher in supplemented infants at 6, 12, 18 and 30 months than in those without supplements. Health indicators, measured by number of self-reported illness related symptoms, differed according to supplementation. These findings indicated that, even if optimal food intake could supply the recommended quantity of vitamins, the risk of marginal deficiency always remained higher in infants without supplementation.
在婴儿期,从天然来源或作为补充剂摄入足够的维生素至关重要。对325名婴儿从出生到三岁期间的食物摄入、维生素补充情况及健康状况进行了维生素状况研究。此处仅呈现维生素A、C、E和叶酸的数据。人工喂养婴儿血清维生素C水平低于0.30毫克/分升的比例是母乳喂养婴儿的4.0倍(P<0.002),血清维生素E水平低于0.35毫克/分升的比例是母乳喂养婴儿的2.2倍(P<0.05)。两组中叶酸水平低于6.0纳克/毫升的婴儿比例相同。未观察到血清维生素A水平低于40微克/分升的婴儿。发现6个月时40%的婴儿、12个月时10%的婴儿每日维生素C食物摄入量低于推荐营养素摄入量(RNI)的80%,18个月及之后则没有。维生素A也呈现类似趋势。95%的婴儿维生素E摄入量、75%的婴儿叶酸摄入量低于RNI的80%。显然,在6、12、18和30个月时,补充维生素的婴儿血清维生素A和C的平均水平显著高于未补充的婴儿。通过自我报告的与疾病相关症状数量衡量的健康指标因是否补充维生素而有所不同。这些发现表明,即使最佳食物摄入量能够提供推荐量的维生素,未补充维生素的婴儿出现边缘性缺乏的风险始终更高。