Wilson's disease (WD) is an autosomal recessive disorder characterized by abnormal copper metabolism. Disruptions in copper metabolism lead to excessive copper deposition in the liver, nervous system, kidneys, heart, and other organs, thereby inducing a range of pathological manifestations and clinical symptoms. Traditional Chinese Medicine (TCM) has demonstrated significant therapeutic efficacy and excellent safety profiles. When integrated with effective Western anti-copper therapies, it can yield superior therapeutic outcomes. Consequently, TCM has exhibited unique advantages in managing WD, particularly when combined with multiple systemic damages. This paper discusses the pathological mechanisms and TCM etiology and pathogenesis of WD combined with multiple organ damage. It also summarizes the clinical efficacy and mechanism of TCM in treating WD combined with multiple organ damage, aiming to provide a reference for further studies on the role and potential mechanisms of TCM interventions in WD.