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含富血小板血浆的伤口愈合生物材料的最新研究进展

Recent Research Progress of Wound Healing Biomaterials Containing Platelet-Rich Plasma.

作者信息

Huang Sha, Li Qing, Li Xiangyu, Ye Hailing, Zhang Luyang, Zhu Xiaoyi

机构信息

Department of Plastic Surgery, Shulan (Hangzhou) Hospital, Hangzhou, Zhejiang, People's Republic of China.

Department of Electrocardiogram, The Second Affiliated Hospital, Zhejiang University School of College, Hangzhou, Zhejiang, People's Republic of China.

出版信息

Int J Nanomedicine. 2025 Mar 31;20:3961-3976. doi: 10.2147/IJN.S506677. eCollection 2025.

Abstract

Platelet-Rich Plasma (PRP) is a plasma product obtained by centrifuging autologous blood, containing a high concentration of platelets, white blood cells, and fibrin. PRP is enriched with various growth factors, such as Transforming Growth Factor-beta (TGF-β), Platelet-Derived Growth Factor (PDGF), Epidermal Growth Factor (EGF), Insulin-Like Growth Factor (IGF), and Vascular Endothelial Growth Factor (VEGF), all of which promote tissue growth and repair. Currently, PRP has been widely applied in the clinical field of wound repair and has achieved certain therapeutic effects. Biomaterials, as an important direction in the treatment of wounds, combined with PRP, provide new possibilities to enhance the regenerative repair of wounds by PRP. This article reviews the latest research progress of biomaterials combined with PRP in the treatment of wounds, aiming to provide references for PRP wound treatment, as well as to provide ideas for the development of subsequent medical materials.

摘要

富血小板血浆(PRP)是一种通过离心自体血液获得的血浆制品,含有高浓度的血小板、白细胞和纤维蛋白。PRP富含多种生长因子,如转化生长因子-β(TGF-β)、血小板衍生生长因子(PDGF)、表皮生长因子(EGF)、胰岛素样生长因子(IGF)和血管内皮生长因子(VEGF),所有这些生长因子都能促进组织生长和修复。目前,PRP已广泛应用于伤口修复的临床领域,并取得了一定的治疗效果。生物材料作为伤口治疗的一个重要方向,与PRP相结合,为增强PRP对伤口的再生修复提供了新的可能性。本文综述了生物材料与PRP联合治疗伤口的最新研究进展,旨在为PRP伤口治疗提供参考,同时为后续医用材料的研发提供思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a83/11970316/7ab74139d99b/IJN-20-3961-g0001.jpg

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