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内镜超声引导下腺泡细胞癌化学消融术作为不可切除疾病的抑制策略

Endoscopic Ultrasound-Guided Chemoablation of an Acinar Cell Carcinoma as a Suppressive Strategy for Unresectable Disease.

作者信息

Rodgers Brandon, Moyer Matthew T

机构信息

Division of Gastroenterology and Hepatology, Penn State Milton S. Hershey Medical Center, Hershey, PA.

出版信息

ACG Case Rep J. 2025 Apr 4;12(4):e01664. doi: 10.14309/crj.0000000000001664. eCollection 2025 Apr.

DOI:10.14309/crj.0000000000001664
PMID:40191218
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11970815/
Abstract

Acinar cell carcinoma is a relatively rare pancreatic neoplasm, typically treated with surgical resection and adjuvant chemotherapy; however, definitive treatment protocols are not well established. We describe endoscopic ultrasound-guided chemoablation with fine needle injection of paclitaxel/gemcitabine in conjunction with chemotherapy in a 78-year-old man with a 3.0 × 2.7-cm acinar cell carcinoma who was not a surgical candidate. At 12 months, the mass had reduced in size to 0.9 × 0.9 cm, followed by steady growth to 6 × 4.5 cm at 24 months when the patient died secondary to unrelated causes.

摘要

腺泡细胞癌是一种相对罕见的胰腺肿瘤，通常采用手术切除和辅助化疗进行治疗；然而，确切的治疗方案尚未完全确立。我们描述了对一名78岁、患有3.0×2.7厘米腺泡细胞癌且不适合手术的男性患者，在内镜超声引导下经细针注射紫杉醇/吉西他滨进行化学消融并联合化疗的情况。12个月时，肿块大小缩小至0.9×0.9厘米，随后稳定增长，在24个月时增大至6×4.5厘米，此时患者因 unrelated causes（此处原文有误，应是unrelated causes，意思为无关原因）去世。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7641/11970815/ca65c6b7a313/ac9-12-e01664-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7641/11970815/ca65c6b7a313/ac9-12-e01664-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7641/11970815/ca65c6b7a313/ac9-12-e01664-g001.jpg

相似文献

[1]
Endoscopic Ultrasound-Guided Chemoablation of an Acinar Cell Carcinoma as a Suppressive Strategy for Unresectable Disease.

ACG Case Rep J. 2025-4-4

[2]
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[3]
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[4]
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[6]
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[7]
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[8]
[A case of acinar cell carcinoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration prior to surgical treatment].

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[9]
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[10]
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本文引用的文献

[1]
Comments and illustrations of the European Federation of Societies for Ultrasound in Medicine contrast-enhanced ultrasound guidelines. Rare pancreatic tumors, imaging features on transabdominal ultrasound and EUS with contrast enhancement: Rare epithelial pancreatic tumors: solid pseudopapillary neoplasm, acinar cell carcinoma, mixed neuroendocrine-non-neuroendocrine neoplasms, some rare subtypes of pancreatic adenocarcinoma and pancreatoblastoma.

Endosc Ultrasound. 2024

[2]
Comprehensive review of pancreatic acinar cell carcinoma: epidemiology, diagnosis, molecular features and treatment.

Jpn J Clin Oncol. 2024-3-9

[3]
Successful EUS-guided pancreatic cyst chemoablation safely allows reduction in the frequency of radiographic surveillance: long-term follow-up of randomized prospective data.

Gastrointest Endosc. 2024-6

[4]
Treatment characteristics and outcomes of pure Acinar cell carcinoma of the pancreas - A multicentric European study on radically resected patients.

HPB (Oxford). 2023-11

[5]
Pancreatic acinar cell carcinoma: A comprehensive review.

World J Gastroenterol. 2022-10-28

[6]
EUS-RFA of the pancreas: where are we and future directions.

Transl Gastroenterol Hepatol. 2022-4-25

[7]
The Durability of EUS-Guided Chemoablation of Mucinous Pancreatic Cysts: A Long-Term Follow-Up of the CHARM trial.

Clin Gastroenterol Hepatol. 2022-2

[8]
The Safety and Efficacy of an Alcohol-Free Pancreatic Cyst Ablation Protocol.

Gastroenterology. 2017-8-9

[9]
EUS-guided fine-needle injection of gemcitabine for locally advanced and metastatic pancreatic cancer.

Gastrointest Endosc. 2016-11-23

[10]
Pancreatic adenocarcinoma.

N Engl J Med. 2014-9-11

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