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一个临床难题:为非肥胖人群进行预防性代谢减重手术?

A Clinical Conundrum: Prophylactic Metabolic Bariatric Surgery for People Without Obesity?

作者信息

Papadia Francesco Saverio, Cohen Ricardo Vitor, Di Lorenzo Nicola

机构信息

University of Genoa, Genoa, Italy.

Center for the Treatment of Obesity and Diabetes, Hospital Alemão Oswaldo Cruz, Sao Paolo, Brazil.

出版信息

Obes Surg. 2025 May;35(5):1584-1585. doi: 10.1007/s11695-025-07851-3. Epub 2025 Apr 7.

DOI:10.1007/s11695-025-07851-3
PMID:40192907
Abstract

Revisional metabolic and bariatric surgery (MBS) in patients with a body mass index (BMI) below the obesity threshold (> 30 kg/m) presents complex clinical and ethical challenges. Indications for reoperation vary widely, from acute complications like gastric band slippage to chronic metabolic disorders such as persistent hypoglycemia after Roux-en-Y gastric bypass (RYGB). While some revisional procedures, like elongation of the common limb for malabsorption-related complications, are widely accepted, other interventions remain controversial. The introduction of a distinct ICD code could help classify MBS-related complications and support surgical decision-making independent of BMI. Additionally, the role of obesity management medications (OMMs) complicates the landscape, as their discontinuation often leads to weight regain. The prophylactic use of MBS to prevent future weight gain is highly debated and risks expanding surgical indications inappropriately. Establishing clear guidelines for revisional surgery in non-obese patients with complications is crucial to ensure justified and effective interventions.

摘要

对体重指数(BMI)低于肥胖阈值(>30kg/m²)的患者进行代谢和减重手术(MBS)翻修手术,会带来复杂的临床和伦理挑战。再次手术的适应症差异很大,从胃束带滑脱等急性并发症到诸如Roux-en-Y胃旁路术(RYGB)后持续性低血糖等慢性代谢紊乱。虽然一些翻修手术,如针对吸收不良相关并发症延长共同肠袢,已被广泛接受,但其他干预措施仍存在争议。引入独特的国际疾病分类(ICD)编码有助于对MBS相关并发症进行分类,并支持独立于BMI的手术决策。此外,肥胖管理药物(OMM)的作用使情况变得复杂,因为停用这些药物往往会导致体重反弹。预防性使用MBS以防止未来体重增加备受争议,且有不适当扩大手术适应症的风险。为有并发症的非肥胖患者制定明确的翻修手术指南,对于确保合理有效的干预措施至关重要。

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本文引用的文献

1
Dumping Syndrome After One Anastomosis Gastric Bypass-A Systematic Review.单吻合口胃旁路术后倾倒综合征——一项系统评价
Obes Surg. 2025 Apr 17. doi: 10.1007/s11695-025-07860-2.
2
Letter to the Editor: Weight Maintenance as an Indication for Metabolic and Bariatric Surgery.致编辑的信:体重维持作为代谢和减重手术的一个指征。
Obes Surg. 2025 May;35(5):1961-1962. doi: 10.1007/s11695-025-07785-w. Epub 2025 Mar 20.
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JAMA Netw Open. 2024 Jun 3;7(6):e2414340. doi: 10.1001/jamanetworkopen.2024.14340.
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Biliopancreatic diversion for severe obesity: long-term weight maintenance and occurrence of nutritional complications are two facets of the same coin.胆胰分流术治疗严重肥胖症:长期体重维持和营养并发症的发生是同一问题的两个方面。
Br J Surg. 2024 Mar 2;111(3). doi: 10.1093/bjs/znae058.
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Pyrrhic victory? Long-term results of biliopancreatic diversion on patients with type 2 diabetes and severe obesity.似是而非的胜利?胆胰分流术治疗 2 型糖尿病合并重度肥胖患者的长期结果。
Surg Obes Relat Dis. 2023 Oct;19(10):1110-1117. doi: 10.1016/j.soard.2023.04.300. Epub 2023 Apr 11.
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Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension.停用司美格鲁肽后的体重反弹和心脏代谢影响:STEP 1 试验延伸。
Diabetes Obes Metab. 2022 Aug;24(8):1553-1564. doi: 10.1111/dom.14725. Epub 2022 May 19.
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Long-Term Results of Single-Anastomosis Duodeno-ileal Bypass with Sleeve Gastrectomy (SADI-S).单吻合口十二指肠空肠旁路术联合袖状胃切除术(SADI-S)的长期疗效。
Obes Surg. 2022 Mar;32(3):682-689. doi: 10.1007/s11695-021-05879-9. Epub 2022 Jan 15.
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Diabetes Resolution at 10 Years After Biliopancreatic Diversion in Overweight and Class 1 Obese Patients with Type 2 Diabetes.10 年后胆胰转流术治疗超重和 1 型肥胖 2 型糖尿病患者的糖尿病缓解情况。
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