Achari A, Radvanyi F R, Scott D, Bon C, Sigler P B
J Biol Chem. 1985 Aug 5;260(16):9385-7.
The phospholipasic presynaptic neurotoxin, crotoxin, has been crystallized in a morphology suitable for single crystal x-ray diffraction analysis. The conditions for growth and the unit cell parameters (P4(1)22 or P4(3)22, a = b = 38.5 A, c = 256.9 A, 1 molecule/asymmetric unit) are similar to the very thin plate-like crystals which have been studied with electron diffraction and electron microscopy by Chiu and his colleagues (Jeng, T.-W., Chiu, W., Zemlin, F., and Zeitler, E. (1984) J. Mol. Biol. 175, 93 - 97). These two macroscopic crystal morphologies of what is likely to be a very similar, if not identical, lattice structure will permit the complementary application of electron diffraction/microscopy and x-ray diffraction to understanding the structural basis of the interactions between a phospholipasic neurotoxin and its membrane target.
磷脂酶突触前神经毒素响尾蛇毒素已结晶成适合单晶X射线衍射分析的形态。其生长条件和晶胞参数（P4(1)22或P4(3)22，a = b = 38.5 Å，c = 256.9 Å，1个分子/不对称单位）与邱及其同事用电子衍射和电子显微镜研究过的非常薄的板状晶体相似（Jeng, T.-W., Chiu, W., Zemlin, F., and Zeitler, E. (1984) J. Mol. Biol. 175, 93 - 97）。这两种宏观晶体形态，即使晶格结构不完全相同也很可能非常相似，这将允许电子衍射/显微镜和X射线衍射互补应用，以了解磷脂酶神经毒素与其膜靶点之间相互作用的结构基础。
