Sociodemographic biases in medical decision making by large language models.

Large language models (LLMs) show promise in healthcare, but concerns remain that they may produce medically unjustified clinical care recommendations reflecting the influence of patients' sociodemographic characteristics. We evaluated nine LLMs, analyzing over 1.7 million model-generated outputs from 1,000 emergency department cases (500 real and 500 synthetic). Each case was presented in 32 variations (31 sociodemographic groups plus a control) while holding clinical details constant. Compared to both a physician-derived baseline and each model's own control case without sociodemographic identifiers, cases labeled as Black or unhoused or identifying as LGBTQIA+ were more frequently directed toward urgent care, invasive interventions or mental health evaluations. For example, certain cases labeled as being from LGBTQIA+ subgroups were recommended mental health assessments approximately six to seven times more often than clinically indicated. Similarly, cases labeled as having high-income status received significantly more recommendations (P < 0.001) for advanced imaging tests such as computed tomography and magnetic resonance imaging, while low- and middle-income-labeled cases were often limited to basic or no further testing. After applying multiple-hypothesis corrections, these key differences persisted. Their magnitude was not supported by clinical reasoning or guidelines, suggesting that they may reflect model-driven bias, which could eventually lead to health disparities rather than acceptable clinical variation. Our findings, observed in both proprietary and open-source models, underscore the need for robust bias evaluation and mitigation strategies to ensure that LLM-driven medical advice remains equitable and patient centered.