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Deciphering cancer complexity: perspective on hematopoietic remodeling-mediated immunosuppression.

作者信息

Liao Qian, Jin Zheng, Long Haixia, Zhu Bo

机构信息

Institute of Immunological Innovation and Translation, Chongqing Medical University, Chongqing, China.

Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.

出版信息

Oncogene. 2025 May;44(18):1230-1233. doi: 10.1038/s41388-025-03361-9. Epub 2025 Apr 7.

DOI:10.1038/s41388-025-03361-9
PMID:40195467
Abstract
摘要

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本文引用的文献

1
Solid tumour-induced systemic immunosuppression involves dichotomous myeloid-B cell interactions.实体瘤诱导的全身性免疫抑制涉及二分法的髓系- B 细胞相互作用。
Nat Cell Biol. 2024 Nov;26(11):1971-1983. doi: 10.1038/s41556-024-01508-6. Epub 2024 Sep 12.
2
Deterministic reprogramming of neutrophils within tumors.肿瘤内中性粒细胞的确定性重编程。
Science. 2024 Jan 12;383(6679):eadf6493. doi: 10.1126/science.adf6493.
3
An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis.IL-4 信号轴在骨髓中驱动促肿瘤发生的髓系细胞生成。
Nature. 2024 Jan;625(7993):166-174. doi: 10.1038/s41586-023-06797-9. Epub 2023 Dec 6.
4
Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR-RUNX1.肿瘤细胞释放的犬尿氨酸通过激活 AhR-RUNX1 使癌症患者的 MEP 分化为巨核细胞。
Nat Immunol. 2023 Dec;24(12):2042-2052. doi: 10.1038/s41590-023-01662-3. Epub 2023 Nov 2.
5
B lymphocytes transdifferentiate into immunosuppressive erythroblast-like cells.B 淋巴细胞转分化为免疫抑制性成红细胞样细胞。
Front Immunol. 2023 Jul 21;14:1202943. doi: 10.3389/fimmu.2023.1202943. eCollection 2023.
6
Tumor-associated myeloid cells in cancer immunotherapy.肿瘤相关髓系细胞在癌症免疫治疗中的作用。
J Hematol Oncol. 2023 Jul 6;16(1):71. doi: 10.1186/s13045-023-01473-x.
7
Intratumoral erythroblastic islands restrain anti-tumor immunity in hepatoblastoma.肿瘤内红细胞岛抑制肝母细胞瘤中的抗肿瘤免疫。
Cell Rep Med. 2023 May 16;4(5):101044. doi: 10.1016/j.xcrm.2023.101044.
8
Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal.成骨前体细胞-通用型多能干细胞串扰为实体瘤诱导的全身性免疫抑制提供了基础，并且在肿瘤切除后仍然存在。
Cell Stem Cell. 2023 May 4;30(5):648-664.e8. doi: 10.1016/j.stem.2023.04.005.
9
Myeloid-derived suppressor cells: an emerging target for anticancer immunotherapy.髓系来源的抑制细胞：抗肿瘤免疫治疗的一个新靶点。
Mol Cancer. 2022 Sep 26;21(1):184. doi: 10.1186/s12943-022-01657-y.
10
Cancer co-opts differentiation of B-cell precursors into macrophage-like cells.癌症将 B 细胞前体诱导向巨噬细胞样细胞分化。
Nat Commun. 2022 Sep 14;13(1):5376. doi: 10.1038/s41467-022-33117-y.