Ding Xiaoxia, Xi Youxia, Sheng Yeyu, Fan Yibin, Yu Yong
Center for Plastic & Reconstructive Surgery, Department of Dermatology, Affiliated People'S Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Department of Dermatology and Venereology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Sci Rep. 2025 Apr 8;15(1):11929. doi: 10.1038/s41598-025-96756-3.
Rosacea, an inflammatory skin disorder with complex pathogenesis, remains poorly understood. Through integrative bioinformatics and experimental approaches, we identified 304 differentially expressed genes in erythrotelangiectasia rosacea (ETR), primarily enriched in lipid metabolism pathways. Support vector machine (SVM), linear regression analyses and network analysis revealed ACADVL and ACSL5 as potential therapeutic targets. Immunological profiling demonstrated distinctive immune cell infiltration, with elevated M0 and M1 macrophages in patients with ETR. Immunofluorescence validation confirmed significant ACSL5 upregulation and increased M1 macrophage infiltration in the rosacea mouse model. The co-localization of ACSL5 with M1 macrophage markers suggests a mechanistic link between lipid metabolism and inflammatory responses. These findings provide new insights into ETR pathogenesis and highlight ACSL5 as a promising therapeutic target for inflammatory skin disorders.
酒渣鼻是一种发病机制复杂的炎症性皮肤病，目前人们对其了解仍然有限。通过整合生物信息学和实验方法，我们在红斑毛细血管扩张型酒渣鼻（ETR）中鉴定出304个差异表达基因，主要富集于脂质代谢途径。支持向量机（SVM）、线性回归分析和网络分析显示ACADVL和ACSL5是潜在的治疗靶点。免疫分析表明存在独特的免疫细胞浸润，ETR患者的M0和M1巨噬细胞水平升高。免疫荧光验证证实酒渣鼻小鼠模型中ACSL5显著上调且M1巨噬细胞浸润增加。ACSL5与M1巨噬细胞标志物的共定位表明脂质代谢与炎症反应之间存在机制联系。这些发现为ETR的发病机制提供了新见解，并突出了ACSL5作为炎症性皮肤病有前景的治疗靶点。
