口服消胆胺对大剂量甲氨蝶呤消除的影响。
Effect of oral cholestyramine on the elimination of high-dose methotrexate.
作者信息
Erttmann R, Landbeck G
出版信息
J Cancer Res Clin Oncol. 1985;110(1):48-50. doi: 10.1007/BF00402501.
Abstract
The anion exchange resin cholestyramine binds methotrexate (MTX) effectively in vitro. The binding capacity exceeds that of activated charcoal by a factor of 5.4. On two patients undergoing high-dose MTX therapy it is also shown that cholestyramine binds MTX in vivo. This leads to an enhanced non-renal excretion of MTX. Therefore, cholestyramine may be of clinical value in patients who develop renal function impairment whilst undergoing MTX therapy.
摘要
阴离子交换树脂消胆胺在体外能有效结合甲氨蝶呤（MTX）。其结合能力比活性炭高出5.4倍。在两名接受大剂量MTX治疗的患者中也表明，消胆胺在体内能结合MTX。这导致MTX的非肾排泄增加。因此，消胆胺对于在MTX治疗期间出现肾功能损害的患者可能具有临床价值。
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