Liu Jinlong, Li Yijing, Lian Xueqi, Zhang Chenglin, Feng Jianing, Tao Hongfei, Wang Zhimin
School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Centre for Cell and Gene Therapy, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
Front Immunol. 2025 Mar 24;16:1517519. doi: 10.3389/fimmu.2025.1517519. eCollection 2025.
Matrix metalloproteinases are integral to the modification of the tumor microenvironment and facilitate tumor progression by degrading the extracellular matrix, releasing cytokines, and influencing the recruitment of immune cells. Among the matrix metalloproteinases, membrane-type matrix metalloproteinase 1 (MT1-MMP/MMP14) is the first identified membrane-type MMP and acts as an essential proteolytic enzyme that enables tumor infiltration and metastatic progression. Given the pivotal role of MT1-MMP in tumor progression and the correlation between its overexpression in tumors and unfavorable prognoses across multiple cancer types, a comprehensive understanding of the potential functional mechanisms of MT1-MMP is essential. This knowledge will aid in the advancement of diverse anti-tumor therapies aimed at targeting MT1-MMP. Although contemporary research has highlighted the considerable potential of MT1-MMP in targeted cancer therapy, studies pertaining to its application in cell therapy remain relatively limited. In this review, we delineate the structural characteristics and regulatory mechanisms of MT1-MMP expression, as well as its biological significance in tumorigenesis. Finally, we discussed the current status and prospects of anti-tumor therapies targeting MT1-MMP.
基质金属蛋白酶对于肿瘤微环境的重塑不可或缺，它通过降解细胞外基质、释放细胞因子以及影响免疫细胞募集来促进肿瘤进展。在基质金属蛋白酶中，膜型基质金属蛋白酶1（MT1-MMP/MMP14）是首个被鉴定出的膜型MMP，作为一种关键的蛋白水解酶，它能够促使肿瘤浸润和转移进展。鉴于MT1-MMP在肿瘤进展中的关键作用，以及其在多种癌症类型肿瘤中的过表达与不良预后之间的相关性，全面了解MT1-MMP的潜在功能机制至关重要。这一知识将有助于推进旨在靶向MT1-MMP的多种抗肿瘤疗法。尽管当代研究突出了MT1-MMP在靶向癌症治疗中的巨大潜力，但其在细胞治疗中的应用相关研究仍然相对有限。在本综述中，我们阐述了MT1-MMP表达的结构特征和调控机制，以及其在肿瘤发生中的生物学意义。最后，我们讨论了靶向MT1-MMP的抗肿瘤疗法的现状和前景。
