Allgire J F, Juenge E C, Damo C P, Sullivan G M, Kirchhoefer R D
J Chromatogr. 1985 May 29;325(1):249-54. doi: 10.1016/s0021-9673(00)96025-4.
A procedure for the determination of the ratio of d- to l-epinephrine in lidocaine-epinephrine local anesthetics is described. Epinephrine was isolated via Sep-Pak cartridges and derivatized with 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl isothiocyanate; the d- and l-chiral derivatives were separated and measured by high-performance liquid chromatography. About 70 samples of various dosage forms and concentrations from four manufacturers were successfully analyzed by the method.
描述了一种测定利多卡因-肾上腺素局部麻醉剂中d-肾上腺素与l-肾上腺素比例的方法。通过Sep-Pak柱分离肾上腺素，并用2,3,4,6-四-O-乙酰基-β-D-吡喃葡萄糖基异硫氰酸酯进行衍生化；通过高效液相色谱法分离并测定d-和l-手性衍生物。该方法成功分析了来自四个制造商的约70种不同剂型和浓度的样品。
