Huston J P, Bixler D, Yu P I
J Craniofac Genet Dev Biol. 1985;5(2):167-73.
Eighteen families each with two or more cleft lip and palate patients were studied by speech cephalometry for evidence of velopharyngeal inadequacy (VPI). With this total of 56 persons, three groups were recognized: 1) patients with cleft lip only (N = 7), 2) unaffected sibs of CL(P) probands and the unaffected parents with the positive clefting history on their side of the family (N = 33), and 3) unaffected parents with negative CL(P) history to their side of the family (N = 16). The latter served as controls. The velopharyngeal mechanism in function was evaluated by voicing the fricative/S/. The results showed no significant differences in the length of either the resting soft palate or pharyngeal depth among the three groups. Even though a significant (P less than 0.01) increase in soft palate length while voicing /S/ was found in group 2 relatives compared to group 3 controls, the failure to find differences in either resting palate length or pharyngeal depth coupled with a failure to demonstrate VPI in group 2 subjects by speech testing leaves the value of this observation uncertain.
对18个每家都有两名或更多唇腭裂患者的家庭进行了语音头影测量研究，以寻找腭咽闭合不全（VPI）的证据。在这总共56人中，分为三组：1）仅唇裂患者（N = 7），2）唇腭裂（CL(P)）先证者的未患病同胞以及家族中该侧有阳性腭裂病史的未患病父母（N = 33），3）家族中该侧无唇腭裂（CL(P)）病史的未患病父母（N = 16）。后者作为对照。通过发摩擦音/S/来评估腭咽机制的功能。结果显示，三组之间静息软腭长度或咽深均无显著差异。尽管与第3组对照相比，第2组亲属在发/S/音时软腭长度有显著（P < 0.01）增加，但静息腭长度或咽深未发现差异，且通过语音测试在第2组受试者中未证实存在VPI，使得这一观察结果的价值不确定。
