Huang Qun, Luan Junjun, Zhou Hua
Department of Nephrology, Shengjing Hospital of China Medical University, 36 Sanhao St, Shenyang, 110000, Liaoning, China.
J Med Case Rep. 2025 Apr 7;19(1):165. doi: 10.1186/s13256-025-05192-4.
Kartagener syndrome is characterized by chronic sinusitis, bronchiectasis, and total visceral transposition. While there are few reports of Kartagener syndrome combined with kidney disease, there are none that specifically report Kartagener syndrome in conjunction with minimal change disease. This is the first report of a rare case of Kartagener syndrome with minimal change disease, which presented with the typical triad and was clinically diagnosed.
A 24-year-old Chinese woman was admitted to the hospital with 2 weeks of foamy urine and edema of the eyelid and lower limbs. After admission, the examination indicated nephrotic syndrome and total visceral transposition. Computed tomography imaging revealed sinusitis bronchiectasis, and she was diagnosed with minimal change disease with Kartagener syndrome. A renal biopsy revealed minimal changes. After symptomatic antiinflammatory therapy, the patient was given telmisartan 50 mg orally once daily to reduce urinary protein levels. A total of 1 month after discharge, her 24-h urine protein content was < 1 g, with normal liver function and improved kidney disease.
We describe a rare case of Kartagener syndrome accompanied by glomerular disease and minimal change disease. The patient was treated symptomatically with antiinflammatory agents and will be monitored long term. We believe our findings will provide valuable guidance and reference for the treatment of such cases in the future.
卡塔格内综合征的特征为慢性鼻窦炎、支气管扩张和完全性内脏转位。虽然卡塔格内综合征合并肾脏疾病的报道较少，但尚无专门报道卡塔格内综合征合并微小病变病的情况。本文首次报道了一例罕见的卡塔格内综合征合并微小病变病的病例，该病例具有典型三联征并经临床诊断。
一名24岁中国女性因2周的泡沫尿及眼睑和下肢水肿入院。入院后检查提示为肾病综合征和完全性内脏转位。计算机断层扫描成像显示鼻窦炎和支气管扩张，诊断为卡塔格内综合征合并微小病变病。肾活检显示微小病变。经对症抗炎治疗后，给予患者口服替米沙坦50毫克，每日一次以降低尿蛋白水平。出院1个月后，其24小时尿蛋白含量<1克，肝功能正常，肾病有所改善。
我们描述了一例罕见的卡塔格内综合征伴肾小球疾病及微小病变病的病例。该患者接受了对症抗炎治疗，并将长期接受监测。我们相信我们的发现将为未来此类病例的治疗提供有价值的指导和参考。
