Vali Yasamin, Dingemanse Walter, Müller-Gerbl Magdalena, Ludewig Eberhard, van Bree Henri, Gielen Ingrid
Diagnostic Imaging, Department of Companion Animals and Horses, University of Veterinary Medicine Vienna (Vetmeduni), Veterinärplatz 1, Vienna, 1210, Austria.
, Bristol, UK.
BMC Vet Res. 2025 Apr 7;21(1):252. doi: 10.1186/s12917-025-04683-2.
Osteochondritis dissecans (OCD) and osteochondrosis (OC) are multifactorial developmental joint diseases that can occur in various anatomical locations, including the tarsus of immature, rapidly growing large breed dogs. The pathogenesis of canine OCD and OC involves a disruption in endochondral ossification, resulting in a failure of matrix calcification and vascular invasion. This study aimed to investigate the subchondral bone density changes in Labrador Retrievers with tarsocrural OCD/ OC.
A total of 8 dogs with unilateral tarsocrural OCD/ OC were included in the study and density was evaluated with Computed Tomography osteoabsorptiometry (CTOAM ). The findings revealed a significant decrease in subchondral bone density at the location of the OCD/ OC lesion, particularly at the medial trochlear ridge. This area of low density was surrounded by a higher density rim. Furthermore, the contralateral joint showed a significantly higher overall mineral density.
These results highlight the significant changes in bone mineral density associated with tarsocrural OCD/ OC. The lower density in the affected joint suggests pathological alterations in the subchondral bone, which may impact the bone turnover and contribute to the development of secondary osteoarthrosis, subsequently. The higher density observed in the contralateral joint emphasizes the role of altered joint loading and adaptation in the subchondral bone.
剥脱性骨软骨炎（OCD）和骨软骨病（OC）是多因素导致的发育性关节疾病，可发生于各种解剖部位，包括未成熟、快速生长的大型犬的跗骨。犬OCD和OC的发病机制涉及软骨内成骨的破坏，导致基质钙化和血管侵入失败。本研究旨在调查患有跗关节OCD/OC的拉布拉多猎犬的软骨下骨密度变化。
本研究共纳入8只单侧跗关节OCD/OC犬，并采用计算机断层扫描骨吸收测定法（CTOAM）评估密度。结果显示，OCD/OC病变部位的软骨下骨密度显著降低，尤其是在内侧滑车嵴处。这个低密度区域被更高密度的边缘包围。此外，对侧关节显示出明显更高的总体矿物质密度。
这些结果突出了与跗关节OCD/OC相关的骨矿物质密度的显著变化。患侧关节较低的密度表明软骨下骨存在病理改变，这可能会影响骨转换，并随后导致继发性骨关节炎的发展。在对侧关节观察到的较高密度强调了关节负荷改变和软骨下骨适应的作用。
