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使用夏尔巴心脏保存系统评估心脏移植结果。

Evaluating Heart Transplant Outcomes Using the SherpaPak Heart Storage System.

作者信息

Finkbiner Spencer, Dalia Tarun, Mancuso Joseph, Baer Jacob, Farhoud Hassan, Foster Keith, Danter Matthew, Zorn Tyler, Hu Jinxiang, Baker Jordan, Shah Hirak, Shah Zubair, Downey Peter, Vidic Andrija

机构信息

From The University of Kansas School of Medicine, Kansas City, Kansas.

Department of Heart Failure and Transplant Cardiology, University of Kansas Medical Center, Kansas City, Kansas.

出版信息

ASAIO J. 2025 Apr 8. doi: 10.1097/MAT.0000000000002431.

Abstract

The SherpaPak Cardiac Transport System (SCTS) is a novel hypothermic organ transport device which maintains an optimal temperature range of 4-8°C during donor heart transport. Its use in many major transplant centers has increased over the last several years. We retrospectively examined 120 heart transplant patients, 60 using SCTS and 60 using traditional cold storage on ice (TCS), at the University of Kansas Medical Center (KUMC) between June 2020 and June 2023. Baseline characteristics were comparable except there were less males in TCS versus SCTS (70% vs. 85%; p = 0.049) and less diabetics (23% vs. 47%; p = 0.07). The TCS group had significantly shorter ischemic times than the SCTS group (177 vs. 204 min; p = 0.008). On analysis, no statistically significant difference was noted in primary graft dysfunction (PGD; 12% vs. 15%; p = 0.59), total length of stay (LOS; 19 vs. 17 days; p = 0.061), 1 year all-cause mortality (12% vs. 8.4%; p = 0.196), and 1 year cardiac allograft vasculopathy (CAV; 58% vs. 63%, p = 0.333] between these two groups. Multivariate analysis also showed no significant difference in PGD and LOS between groups. We conclude that despite having longer ischemic times in the SCTS group, the post-transplant outcomes were comparable to TCS.

摘要

夏尔巴心脏运输系统(SCTS)是一种新型的低温器官运输设备,在供体心脏运输过程中可将温度维持在4-8°C的最佳范围内。在过去几年中,它在许多主要移植中心的使用有所增加。我们回顾性研究了2020年6月至2023年6月期间在堪萨斯大学医学中心(KUMC)进行心脏移植的120例患者,其中60例使用SCTS,60例使用传统冰上冷藏(TCS)。除了TCS组的男性患者少于SCTS组(70%对85%;p=0.049)和糖尿病患者较少(23%对47%;p=0.07)外,两组的基线特征具有可比性。TCS组的缺血时间明显短于SCTS组(177分钟对204分钟;p=0.008)。分析显示,两组在原发性移植物功能障碍(PGD;12%对15%;p=0.59)、总住院时间(LOS;19天对17天;p=0.061)、1年全因死亡率(12%对8.4%;p=0.196)和1年心脏移植血管病变(CAV;58%对63%,p=0.333)方面无统计学显著差异。多变量分析也显示两组在PGD和LOS方面无显著差异。我们得出结论,尽管SCTS组的缺血时间较长,但移植后的结果与TCS相当。

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