Translational Modeling as a Tool to Evaluate the Effectiveness of Nalmefene in a Community Setting: A Critical Perspective.
作者信息
Laffont Celine M, de la Peña Amparo, Skolnick Phil
机构信息
Research and Development, Indivior, Inc., Richmond, Virginia, USA.
Clinical Pharmacology and Pharmacometrics Solutions, Simulations Plus, Buffalo, New York, USA.
出版信息
Clin Pharmacol Ther. 2025 Jul;118(1):25-26. doi: 10.1002/cpt.3668. Epub 2025 Apr 8.
Abstract
摘要
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本文引用的文献
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Toward Developing Alternative Opioid Antagonists for Treating Community Overdose: A Model-Based Evaluation of Important Pharmacological Attributes.开发用于治疗社区药物过量的替代性阿片类拮抗剂：基于模型的重要药理学特性评估
Clin Pharmacol Ther. 2025 Mar;117(3):836-845. doi: 10.1002/cpt.3527. Epub 2025 Jan 28.
2
Comparison of intranasal naloxone and intranasal nalmefene in a translational model assessing the impact of synthetic opioid overdose on respiratory depression and cardiac arrest.在一个评估合成阿片类药物过量对呼吸抑制和心脏骤停影响的转化模型中，比较鼻内注射纳洛酮和鼻内注射纳美芬的效果。
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3
Reversal of Opioid-Induced Respiratory Depression in Healthy Volunteers: Comparison of Intranasal Nalmefene and Intranasal Naloxone.健康志愿者中阿片类药物引起的呼吸抑制的逆转：鼻内纳美芬与鼻内纳洛酮的比较。
J Clin Pharmacol. 2024 Jul;64(7):828-839. doi: 10.1002/jcph.2421. Epub 2024 Mar 4.
4
Pharmacokinetic Properties of an FDA-approved Intranasal Nalmefene Formulation for the Treatment of Opioid Overdose.一种经美国食品药品监督管理局批准的用于治疗阿片类药物过量的鼻腔内纳美芬制剂的药代动力学特性。
Clin Pharmacol Drug Dev. 2024 Jan;13(1):58-69. doi: 10.1002/cpdd.1312. Epub 2023 Jul 27.
5
Development of a Translational Model to Assess the Impact of Opioid Overdose and Naloxone Dosing on Respiratory Depression and Cardiac Arrest.开发一种转化模型，以评估阿片类药物过量和纳洛酮给药对呼吸抑制和心脏骤停的影响。
Clin Pharmacol Ther. 2022 Nov;112(5):1020-1032. doi: 10.1002/cpt.2696. Epub 2022 Jul 22.
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