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Translational Modeling as a Tool to Evaluate the Effectiveness of Nalmefene in a Community Setting: A Critical Perspective.

作者信息

Laffont Celine M, de la Peña Amparo, Skolnick Phil

机构信息

Research and Development, Indivior, Inc., Richmond, Virginia, USA.

Clinical Pharmacology and Pharmacometrics Solutions, Simulations Plus, Buffalo, New York, USA.

出版信息

Clin Pharmacol Ther. 2025 Jul;118(1):25-26. doi: 10.1002/cpt.3668. Epub 2025 Apr 8.

DOI:10.1002/cpt.3668
PMID:40197652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12166269/
Abstract
摘要

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Translational Modeling as a Tool to Evaluate the Effectiveness of Nalmefene in a Community Setting: A Critical Perspective.转化模型作为评估纳美芬在社区环境中有效性的工具：批判性视角
Clin Pharmacol Ther. 2025 Jul;118(1):25-26. doi: 10.1002/cpt.3668. Epub 2025 Apr 8.
2
Reply to "Translational Modeling as a Tool to Evaluate the Effectiveness of Nalmefene in a Community Setting: A Critical Perspective".对《将转化模型作为评估纳美芬在社区环境中有效性的工具：批判性视角》的回复
Clin Pharmacol Ther. 2025 Jul;118(1):27-28. doi: 10.1002/cpt.3669. Epub 2025 Apr 8.
3
Comparison of intranasal naloxone and intranasal nalmefene in a translational model assessing the impact of synthetic opioid overdose on respiratory depression and cardiac arrest.在一个评估合成阿片类药物过量对呼吸抑制和心脏骤停影响的转化模型中，比较鼻内注射纳洛酮和鼻内注射纳美芬的效果。
Front Psychiatry. 2024 Jun 17;15:1399803. doi: 10.3389/fpsyt.2024.1399803. eCollection 2024.
4
The cost-effectiveness and public health benefit of nalmefene added to psychosocial support for the reduction of alcohol consumption in alcohol-dependent patients with high/very high drinking risk levels: a Markov model.纳美芬联合心理社会支持对降低饮酒风险高/极高的酒精依赖患者酒精摄入量的成本效益及公共卫生效益：马尔可夫模型
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Reversal of a synthetic opioid overdose: Insights from a validated translational model.合成阿片类药物过量的逆转：来自一个经过验证的转化模型的见解。
Neuropharmacology. 2025 Nov 1;278:110546. doi: 10.1016/j.neuropharm.2025.110546. Epub 2025 Jun 6.
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The Cost Effectiveness of Nalmefene for Reduction of Alcohol Consumption in Alcohol-Dependent Patients with High or Very High Drinking-Risk Levels from a UK Societal Perspective.从英国社会视角看纳美芬降低饮酒风险高或极高的酒精依赖患者酒精摄入量的成本效益
CNS Drugs. 2016 Feb;30(2):163-77. doi: 10.1007/s40263-016-0310-2.
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Nalmefene for Reducing Alcohol Consumption in People with Alcohol Dependence: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.纳美芬用于减少酒精依赖者的酒精摄入量：英国国家卫生与临床优化研究所单一技术评估的证据审查小组观点
Pharmacoeconomics. 2015 Aug;33(8):833-47. doi: 10.1007/s40273-015-0272-0.
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Who Receives Nalmefene and How Does It Work in the Real World? A Single-Arm, Phase IV Study of Nalmefene in Alcohol Dependent Outpatients: Baseline and 1-Month Results.谁接受纳美芬以及它在现实世界中如何发挥作用？纳美芬治疗酒精依赖门诊患者的单臂、四期研究：基线和 1 个月结果。
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Pharmacokinetic Properties of an FDA-approved Intranasal Nalmefene Formulation for the Treatment of Opioid Overdose.一种经美国食品药品监督管理局批准的用于治疗阿片类药物过量的鼻腔内纳美芬制剂的药代动力学特性。
Clin Pharmacol Drug Dev. 2024 Jan;13(1):58-69. doi: 10.1002/cpdd.1312. Epub 2023 Jul 27.

本文引用的文献

1
Toward Developing Alternative Opioid Antagonists for Treating Community Overdose: A Model-Based Evaluation of Important Pharmacological Attributes.开发用于治疗社区药物过量的替代性阿片类拮抗剂：基于模型的重要药理学特性评估
Clin Pharmacol Ther. 2025 Mar;117(3):836-845. doi: 10.1002/cpt.3527. Epub 2025 Jan 28.
2
Comparison of intranasal naloxone and intranasal nalmefene in a translational model assessing the impact of synthetic opioid overdose on respiratory depression and cardiac arrest.在一个评估合成阿片类药物过量对呼吸抑制和心脏骤停影响的转化模型中，比较鼻内注射纳洛酮和鼻内注射纳美芬的效果。
Front Psychiatry. 2024 Jun 17;15:1399803. doi: 10.3389/fpsyt.2024.1399803. eCollection 2024.
3
Reversal of Opioid-Induced Respiratory Depression in Healthy Volunteers: Comparison of Intranasal Nalmefene and Intranasal Naloxone.健康志愿者中阿片类药物引起的呼吸抑制的逆转：鼻内纳美芬与鼻内纳洛酮的比较。
J Clin Pharmacol. 2024 Jul;64(7):828-839. doi: 10.1002/jcph.2421. Epub 2024 Mar 4.
4
Pharmacokinetic Properties of an FDA-approved Intranasal Nalmefene Formulation for the Treatment of Opioid Overdose.一种经美国食品药品监督管理局批准的用于治疗阿片类药物过量的鼻腔内纳美芬制剂的药代动力学特性。
Clin Pharmacol Drug Dev. 2024 Jan;13(1):58-69. doi: 10.1002/cpdd.1312. Epub 2023 Jul 27.
5
Development of a Translational Model to Assess the Impact of Opioid Overdose and Naloxone Dosing on Respiratory Depression and Cardiac Arrest.开发一种转化模型，以评估阿片类药物过量和纳洛酮给药对呼吸抑制和心脏骤停的影响。
Clin Pharmacol Ther. 2022 Nov;112(5):1020-1032. doi: 10.1002/cpt.2696. Epub 2022 Jul 22.