Yang Jinpeng, Li Yangjiani, Zhang Qi, Zeng Simei, Huang Haishun, Wu Caiqing, Liu Zhe, Tang Jiahui, Wu Siting, Chen Yuze, Zhuo Yehong, Yang Yangfan, Li Yiqing
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):18. doi: 10.1167/iovs.66.4.18.
The purpose of this study was to determine the influence of optic nerve head (ONH) rotation and tilt on the structure-function (S-F) relationship differences between early open-angle glaucoma (OAG) with and without high myopia (HM).
A total of 164 eyes, including 69 early highly myopic glaucoma (HMG) eyes, 60 early OAG eyes, and 35 healthy HM eyes, were included. All the eyes underwent spectral-domain optical coherence tomography, standard automated perimetry, and fundus photography simultaneously. S-F relationships were analyzed by comparing the peripapillary retinal nerve fiber layer thickness (pRNFLT) to the corresponding visual field sensitivity loss (VFSL) according to the Garway-Heath map. Linear regression analyses were used to evaluate the relationship between ONH rotation and tilt with pRNFLT and VFSL.
Multivariate regression analysis demonstrated that the ovality index was associated with nasal (P = 0.014) pRNFLT in OAG eyes and with nasal (P < 0.001), temporal (P = 0.012), and superior nasal (P = 0.015) pRNFLT in healthy HM eyes, but not in HMG eyes. Moreover, ONH rotation was significantly associated with inferior nasal (P = 0.013) pRNFLT in HMG eyes and with inferior temporal (P = 0.029) and inferior nasal (P = 0.036) pRNFLT in healthy HM eyes, whereas no associations were observed in OAG eyes. The strongest relationship between pRNFLT and VFSL for HMG and OAG were found in the inferior temporal (R = 0.567) and superior temporal sector (R = 0.638), respectively. However, no significant relationships were observed in healthy HM eyes (all P > 0.05).
Optic disc rotation and tilt may affect the distribution of the pRNFL in HM eyes with or without glaucoma, resulting in abnormal correspondence between structure and function. The analysis of the S-F relationship in the inferior temporal sector could be a valuable factor in assessing HMG eyes.
本研究旨在确定视神经乳头（ONH）旋转和倾斜对伴有和不伴有高度近视（HM）的早期开角型青光眼（OAG）结构-功能（S-F）关系差异的影响。
共纳入164只眼，包括69只早期高度近视性青光眼（HMG）眼、60只早期OAG眼和35只健康HM眼。所有眼睛同时接受了光谱域光学相干断层扫描、标准自动视野检查和眼底照相。根据Garway-Heath图谱，通过比较视乳头周围视网膜神经纤维层厚度（pRNFLT）与相应的视野敏感度损失（VFSL）来分析S-F关系。采用线性回归分析评估ONH旋转和倾斜与pRNFLT和VFSL之间的关系。
多变量回归分析表明，椭圆率指数与OAG眼中鼻侧（P = 0.014）pRNFLT以及健康HM眼中鼻侧（P < 0.001）、颞侧（P = 0.012）和鼻上侧（P = 0.015）pRNFLT相关，但与HMG眼无关。此外，ONH旋转与HMG眼中鼻下侧（P = 0.013）pRNFLT以及健康HM眼中颞下侧（P = 0.029）和鼻下侧（P = 0.036）pRNFLT显著相关，而在OAG眼中未观察到相关性。HMG和OAG中pRNFLT与VFSL之间最强的关系分别出现在颞下侧（R = 0.567）和颞上侧扇形区（R = 0.638）。然而，在健康HM眼中未观察到显著关系（所有P > 0.05）。
视盘旋转和倾斜可能会影响伴有或不伴有青光眼的HM眼中pRNFL的分布，导致结构与功能之间的对应异常。颞下侧扇形区S-F关系的分析可能是评估HMG眼的一个有价值的因素。
