Ni Weifang, Chen Si-Hua, Dai Le, Zhou Yifu, He Chenjun
Department of Neurosurgery, The Affiliated Hospital of Shaoxing University (Shaoxing Municipal Hospital), No. 999 Zhongxing South Road, Yuecheng District, Shaoxing City 312000 Zhejiang Province, China.
Department of Neurosurgery, The Affiliated Hospital of Shaoxing University (Shaoxing Municipal Hospital), No. 999 Zhongxing South Road, Yuecheng District, Shaoxing City 312000 Zhejiang Province, China.
Clin Chim Acta. 2025 Jun 1;573:120282. doi: 10.1016/j.cca.2025.120282. Epub 2025 Apr 6.
PTEN-induced putative kinase 1 (PINK1) may moderate neurodegeneration via sustaining mitochondrial function and integrity. Here, we attempted to determine relationship between serum PINK1 levels, disease severity, poor prognosis, Early Neurological Deterioration (END) and Stroke-Associated Pneumonia (SAP) following acute Intracerebral Hemorrhage (ICH).
Altogether, 175 patients with ICH and 80 controls were encompassed in this prospective cohort study. Serum PINK1 levels were measured at admission of all patients and at study entry of all controls. The National Institutes of Health Stroke Scale (NIHSS) scores and hematoma volumes were applied to determine the severity. SAP, END and post-ICH 6-month poor prognosis (modified Rankin Scale scores: 3-6) were recorded as the three outcome variables of interest.
Patients, in contrast to controls, had significantly elevated serum PINK1 levels. Serum PINK1 levels were independently correlated with NIHSS scores, hematoma volumes and 6-month modified Rankin Scale scores. Serum PINK1 levels were linearly correlated with risks of SAP, END and post-ICH 6-month poor prognosis under the restricted cubic spline, as well as along with NIHSS scores and hematoma volumes, became their independent predictors. As demonstrated under receiver operating characteristic curve, serum PINK1 levels displayed effective predictive ability and possessed similar discrimination efficiency, when compared to NIHSS scores and hematoma volumes. Using sensitivity analysis, prognosis association was robust.
Serum PINK1 levels are substantially heightened after ICH, and may accurately mirror hemorrhagic intensity and efficaciously forecast END, SAP, and poor neurological prognosis, signifying that PINK1 may be a serological prognosticator of good prospect in ICH.
PTEN诱导的假定激酶1（PINK1）可能通过维持线粒体功能和完整性来减轻神经退行性变。在此，我们试图确定急性脑出血（ICH）后血清PINK1水平、疾病严重程度、预后不良、早期神经功能恶化（END）和卒中相关性肺炎（SAP）之间的关系。
本前瞻性队列研究共纳入175例ICH患者和80例对照。在所有患者入院时和所有对照进入研究时测量血清PINK1水平。应用美国国立卫生研究院卒中量表（NIHSS）评分和血肿体积来确定严重程度。记录SAP、END和ICH后6个月预后不良（改良Rankin量表评分：3 - 6）作为三个感兴趣的结局变量。
与对照组相比，患者血清PINK1水平显著升高。血清PINK1水平与NIHSS评分、血肿体积和6个月改良Rankin量表评分独立相关。在受限立方样条下，血清PINK1水平与SAP、END和ICH后6个月预后不良的风险呈线性相关，并且与NIHSS评分和血肿体积一起成为它们的独立预测因子。如在受试者工作特征曲线下所示，血清PINK1水平显示出有效的预测能力，并且与NIHSS评分和血肿体积相比具有相似的鉴别效率。通过敏感性分析，预后关联是稳健的。
ICH后血清PINK1水平显著升高，并且可能准确反映出血强度并有效预测END、SAP和不良神经预后，这表明PINK1可能是ICH中有良好前景的血清学预后指标。
