Oida Mitsunori, Fujiu Katsuhito, Hasumi Eriko, Oshima Tsukasa, Kani Kunihiro, Goto Kohsaku, Hashimoto Masaki, Kojima Toshiya, Shimizu Yu, Yamagata Kenichiro, Oguri Gaku, Komuro Issei
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.
Department of Advanced Cardiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.
Sci Rep. 2025 Apr 8;15(1):11946. doi: 10.1038/s41598-025-94614-w.
Tricuspid regurgitation (TR) is a well-known complication of pacemaker implantation (PMI). Recently, the conduction system pacing (CSP) technique, which could avoid the development of ventricular dyssynchrony, was established. However, the impact of CSP on TR is unclear. This study aimed to describe the association between CSP and worsening TR. The data of 110 patients who were given a transthoracic echocardiogram (TTE) before and after PMI were retrospectively analyzed. The severity of TR was classified into four groups. Worsening TR was defined as one or more grade increases in TR. Twenty (18.2%) patients had worsening TR, and 7 patients (6.4%) had TR ≥ moderate after PMI. After comparing the patients with and without CSP, 5 (27.8%) and 15 (16.3%) patients, respectively, had worsening TR, but the frequency did not indicate a significant difference (P = 0.25). The frequency of TR ≥ moderate after PMI in the former group was significantly higher than in the latter group at 3 (16.7%) and 4 (4.3%), respectively (P = 0.05). This study revealed that patients with CSP had a higher frequency of TR ≥ moderate after PMI compared to patients without CSP in the medium term.
三尖瓣反流（TR）是起搏器植入（PMI）的一种常见并发症。最近，建立了一种可避免心室不同步发展的传导系统起搏（CSP）技术。然而，CSP对TR的影响尚不清楚。本研究旨在描述CSP与TR恶化之间的关联。对110例在PMI前后接受经胸超声心动图（TTE）检查的患者数据进行回顾性分析。TR的严重程度分为四组。TR恶化定义为TR增加一个或多个等级。20例（18.2%）患者出现TR恶化，7例（6.4%）患者在PMI后TR≥中度。在比较接受和未接受CSP的患者后，分别有5例（27.8%）和15例（16.3%）患者出现TR恶化，但频率无显著差异（P = 0.25）。前一组在PMI后TR≥中度的频率分别为3例（16.7%）和4例（4.3%），显著高于后一组（P = 0.05）。本研究表明，中期来看，与未接受CSP的患者相比，接受CSP的患者在PMI后TR≥中度的频率更高。
