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术前参数对颈椎后纵韧带骨化症所致脊髓病行前后路联合手术(LAMP)疗效的预测作用

Predictive role of preoperative parameters in LAMP outcomes for myelopathy caused by COPLL.

作者信息

Yuan Hao, Lei Wei, Li Wenping, Zhou Yunlong, Jia Xufeng, Feng Daxiong, Lei Fei

机构信息

Spinal Surgery Department, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China.

Department of orthopedics, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

出版信息

BMC Musculoskelet Disord. 2025 Apr 8;26(1):341. doi: 10.1186/s12891-025-08577-0.


DOI:10.1186/s12891-025-08577-0
PMID:40200258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11980283/
Abstract

OBJECTIVES: This study aims to assess the predictive value of preoperative parameters on recovery outcomes in patients with myelopathy caused by cervical ossification of the posterior longitudinal ligament (COPLL) undergoing laminoplasty (LAMP). METHODS: A retrospective analysis was performed on myelopathy patients caused by COPLL who underwent LAMP between 2017 and 2020. Preoperative variables, including basic epidemiological characteristics, comorbidities, functional scores, K-line-related parameters, Torg-Pavlov ratio, maximal SCOR and COPLL shape, were analyzed for their predictive influence on postoperative outcomes in cervical spine function, upper and lower extremity function, bladder function, and quality of life (QOL). Binary logistic regression model analyses were used to evaluate predictive accuracy. RESULTS: A total of 84 patients were included in the study. Preoperative parameters were significant predictors of postoperative improvement following LAMP surgery for myelopathy caused by COPLL. K-line-related factors, including K-line (-) (AUC = 0.80) and K-line on sagittal T1WI (-) (AUC = 0.76), were important predictors of cervical spine function improvement. Preoperative QOL scores (AUC = 0.78) also played a significant role in predicting cervical spine function improvement. For upper extremity function, preoperative upper extremity scores were a key predictor (AUC = 0.79), while C4-C6 K-line (-) (AUC = 0.81) was also a relevant factor. Similarly, preoperative lower extremity scores were crucial for predicting lower extremity function improvement (AUC = 0.85), and preoperative QOL scores were significant predictors of QOL improvement (AUC = 0.78). Other parameters, such as the Torg-Pavlov ratio, maximal SCOR, and the shape of COPLL, provided supplementary predictive value, though their influence was secondary to JOACMEQ scores and K-line parameters. Bladder function showed minimal postoperative improvement, with preoperative bladder status and the Torg-Pavlov ratio at C5 being the primary predictors for bladder improvement. Overall, preoperative K-line findings, JOACMEQ scores, and spinal canal measurements provided valuable guidance for postoperative expectations and surgical planning. CONCLUSIONS: Preoperative K-line parameters and JOACMEQ scores are robust predictors of functional recovery in myelopathy patients caused by COPLL undergoing LAMP. While Torg-Pavlov ratio, maximal SCOR, and the shape of COPLL offer additional predictive value for overall recovery, they remain useful for preoperative surgical planning. These findings emphasize the importance of comprehensive preoperative assessment to optimize outcomes.

摘要

目的:本研究旨在评估术前参数对接受椎板成形术(LAMP)治疗的后纵韧带骨化症(COPLL)所致脊髓病患者恢复结局的预测价值。 方法:对2017年至2020年间接受LAMP治疗的COPLL所致脊髓病患者进行回顾性分析。分析术前变量,包括基本流行病学特征、合并症、功能评分、K线相关参数、Torg-Pavlov比值、最大SCOR和COPLL形态,以评估其对颈椎功能、上肢和下肢功能、膀胱功能及生活质量(QOL)术后结局的预测影响。采用二元逻辑回归模型分析评估预测准确性。 结果:本研究共纳入84例患者。术前参数是LAMP手术治疗COPLL所致脊髓病术后改善的重要预测指标。与K线相关的因素,包括K线(-)(AUC = 0.80)和矢状面T1WI上的K线(-)(AUC = 0.76),是颈椎功能改善的重要预测指标。术前QOL评分(AUC = 0.78)在预测颈椎功能改善方面也发挥了重要作用。对于上肢功能,术前上肢评分是关键预测指标(AUC = 0.79),而C4-C6 K线(-)(AUC = 0.81)也是一个相关因素。同样,术前下肢评分对于预测下肢功能改善至关重要(AUC = 0.85),术前QOL评分是QOL改善的重要预测指标(AUC = 0.78)。其他参数,如Torg-Pavlov比值、最大SCOR和COPLL形态,提供了补充预测价值,但其影响仅次于JOACMEQ评分和K线参数。膀胱功能术后改善最小,术前膀胱状态和C5水平的Torg-Pavlov比值是膀胱改善的主要预测指标。总体而言,术前K线检查结果、JOACMEQ评分和椎管测量为术后预期和手术规划提供了有价值的指导。 结论:术前K线参数和JOACMEQ评分是接受LAMP治疗的COPLL所致脊髓病患者功能恢复的有力预测指标。虽然Torg-Pavlov比值、最大SCOR和COPLL形态为总体恢复提供了额外的预测价值,但它们仍有助于术前手术规划。这些发现强调了全面术前评估对优化结局的重要性。

相似文献

[1]
Predictive role of preoperative parameters in LAMP outcomes for myelopathy caused by COPLL.

BMC Musculoskelet Disord. 2025-4-8

[2]
Anterior cervical corpectomy and fusion versus posterior laminoplasty for the treatment of oppressive myelopathy owing to cervical ossification of posterior longitudinal ligament: a meta-analysis.

Eur Spine J. 2018-6

[3]
The impact of dynamic factors on surgical outcomes after double-door laminoplasty for ossification of the posterior longitudinal ligament of the cervical spine.

J Neurosurg Spine. 2014-12

[4]
Anterior direct decompression significantly relieves spinal cord high signal in patients with ossification of the posterior longitudinal ligament: a case-control study.

J Orthop Surg Res. 2023-11-24

[5]
Factors Associated With Loss of Cervical Lordosis After Laminoplasty for Patients With Cervical Ossification of the Posterior Longitudinal Ligament: Data From a Prospective Multicenter Study.

Spine (Phila Pa 1976). 2023-8-1

[6]
Surgical strategy for cervical myelopathy due to ossification of the posterior longitudinal ligament: Part 1: Clinical results and limitations of laminoplasty.

Spine (Phila Pa 1976). 2007-3-15

[7]
Risk factors associated with upper extremity palsy after expansive open-door laminoplasty for cervical myelopathy.

Spine J. 2014-6-1

[8]
Impact of preoperative cervical sagittal alignment for cervical myelopathy caused by ossification of the posterior longitudinal ligament on surgical treatment.

J Orthop Sci. 2022-11

[9]
A Comparative Study of Anterior Decompression With Fusion and Posterior Decompression With Laminoplasty for the Treatment of Cervical Spondylotic Myelopathy Patients With Large Anterior Compression of the Spinal Cord.

Clin Spine Surg. 2017-10

[10]
C4/5 foraminal stenosis predicts C5 palsy after expansive open-door laminoplasty.

Eur Spine J. 2017-9

本文引用的文献

[1]
Efficacy of Different Doses of Intra-Articular Tranexamic Acid for Reducing Blood Loss and Lower Limb Swelling After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Trial.

Orthop Surg. 2025-3

[2]
Novel Algorithm for Surgical Management of Cervical Ossification of Posterior Longitudinal Ligament: A Retrospective Cohort Study With 2-Year Follow-Up.

Orthop Surg. 2025-2

[3]
Anterior direct decompression significantly relieves spinal cord high signal in patients with ossification of the posterior longitudinal ligament: a case-control study.

J Orthop Surg Res. 2023-11-24

[4]
Comparative study of preoperative sagittal alignment between patients with multisegment cervical ossification of the posterior longitudinal ligament and cervical spondylotic myelopathy.

Spine J. 2023-11

[5]
Effect of K‑line on posterior cervical surgery versus anterior cervical surgery in patients with multi-level ossification of posterior longitudinal ligament.

Eur Spine J. 2023-7

[6]
Neck Disability Index as a Prognostic Factor for Outcomes Following Cervical Disc Replacement.

Clin Spine Surg. 2023-10-1

[7]
Analysis between preoperative cervical radiographic parameters represented by the K-line tilt and the short-term prognosis of laminoplasty for posterior longitudinal ligament ossification: A retrospective study.

Front Surg. 2022-9-22

[8]
A Systematic Review on Neurological Outcomes for Cervical Degenerative Myelopathy After Anterior Decompression Surgery: Motion Preservation vs Fusion.

Int J Spine Surg. 2022-12

[9]
Instrumented fusion versus instrumented non-fusion following expansive open-door laminoplasty for multilevel cervical ossification of the posterior longitudinal ligament.

Arch Orthop Trauma Surg. 2023-6

[10]
Ossification of the Posterior Longitudinal Ligament: Pathophysiology, Diagnosis, and Management.

J Am Acad Orthop Surg. 2022-9-1

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