Zhang Yan-Xi, Albers Richard, Chen Ya-Ting, Steineck Gunnar, Kellen Eliane, Johnson Kenneth C, Lu Chih-Ming, Pohlabeln Hermann, Vecchia Carlo La, Porru Stefano, Carta Angela, Polesel Jerry, Bosetti Cristina, Jiang Xuejuan, Tang Li, Marshall James, Karagas Margaret R, Zhang Zuo-Feng, Taylor Jack A, Zeegers Maurice P A, Wesselius Anke, Yu Evan Yi-Wen
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China.
Department of Epidemiology & Biostatistics, School of Public Health, Southeast University, Nanjing, China.
Nutr Cancer. 2025;77(6):687-698. doi: 10.1080/01635581.2025.2488063. Epub 2025 Apr 8.
Evidence regarding the association between tea consumption and bladder cancer (BC) risk is inconsistent. This study aimed to increase our knowledge of the association by using international data from the Bladder Cancer Epidemiology and Nutritional Determinants Consortium.
Individual data on 2,347 cases and 6,871 controls from 15 case-control studies with information on black, green, herbal, or general tea was pooled. The association was estimated using multilevel multivariable logistic regression analysis adjusted for multiple (non-)dietary factors.
Association between tea consumption and BC risk was observed (odds ratio, OR = 0.72, 95% confidence interval, 95% CI = 0.65-0.80) compared to non-tea drinkers. Stratified analyses based on gender and smoking status yielded similar results. Stratified analysis showed no significant association between black or green tea consumption and BC risk across models, while herbal tea consumption was linked to a reduced BC risk (OR = 0.59, 95% CI = 0.36-0.96). As daily tea consumption increased within a suitable range (<5.67 cups/day), BC risk decreased.
tea showed no association with BC risk, while herbal tea was inversely linked to BC incidence. Despite some significant findings in the selected strata, further studies are required to clarify the underlying mechanisms.
关于饮茶与膀胱癌（BC）风险之间关联的证据并不一致。本研究旨在通过使用来自膀胱癌流行病学和营养决定因素联盟的国际数据，增加我们对这种关联的了解。
汇总了来自15项病例对照研究的2347例病例和6871例对照的个体数据，这些研究包含了关于红茶、绿茶、花草茶或普通茶的信息。使用多水平多变量逻辑回归分析估计这种关联，并对多种（非）饮食因素进行了调整。
与不饮茶者相比，观察到饮茶与BC风险之间存在关联（优势比，OR = 0.72，95%置信区间，95%CI = 0.65 - 0.80）。基于性别和吸烟状况的分层分析得出了类似的结果。分层分析表明，在所有模型中，饮用红茶或绿茶与BC风险之间均无显著关联，而饮用花草茶与BC风险降低有关（OR = 0.59，95%CI = 0.36 - 0.96）。随着每日饮茶量在适宜范围内（<5.67杯/天）增加，BC风险降低。
普通茶与BC风险无关联，而花草茶与BC发病率呈负相关。尽管在所选分层中有一些显著发现，但仍需要进一步研究来阐明潜在机制。
