Hajiesmaeili Yasaman, Mollaahmadi Fahimeh, Borjian Boroujeni Parnaz, Mohseni Meybodi Anahita, Haratian Kaveh
Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Int J Fertil Steril. 2025 Mar 11;19(2):120-132. doi: 10.22074/ijfs.2024.2026567.1661.
Despite the apparent resilience of the male reproductive system, various viruses have been found to impact male fertility by causing testicular inflammation, hormonal imbalances, and sperm abnormalities. The integrity of the genome is vital for cell function, and its instability, influenced by various factors including viral infections, may contribute to age-related conditions such as cancer and neurodegenerative disorders. This scoping review aims to investigate the relationship between viral infections and sperm genetic stability, exploring their interactions and potential impact on male reproductive health and fertility. In order to conduct this scoping review, PubMed, MEDLINE (OVID), ScienceDirect, Google Scholar, and Cochrane databases were explored to find the relevant articles using a search strategy developed in collaboration with a medical librarian. Two independent reviewers screened titles and abstracts of the relevant papers, followed by full-text screening. Studies focusing on infertile males with viral infections, compared to fertile males, examining DNA damage and sperm abnormalities were included. Thirty-four studies were included in the current review. This review will provide valuable information to healthcare professionals in addressing virusinduced sperm genetic instability and its implications for reproductive health. Furthermore, it highlights the socioeconomic and public health aspects of preventing and managing viral infections.
尽管男性生殖系统看似具有恢复力，但已发现多种病毒会通过引发睾丸炎、激素失衡和精子异常来影响男性生育能力。基因组的完整性对细胞功能至关重要，而其不稳定性受包括病毒感染在内的多种因素影响，可能会导致与年龄相关的疾病，如癌症和神经退行性疾病。本综述旨在研究病毒感染与精子遗传稳定性之间的关系，探讨它们的相互作用以及对男性生殖健康和生育能力的潜在影响。为了进行本综述，我们利用与医学图书馆员合作制定的检索策略，对PubMed、MEDLINE（OVID）、ScienceDirect、谷歌学术和Cochrane数据库进行了检索，以查找相关文章。两名独立评审员对相关论文的标题和摘要进行了筛选，随后进行全文筛选。纳入了与生育男性相比，关注病毒感染不育男性、检查DNA损伤和精子异常的研究。本综述纳入了34项研究。本综述将为医疗保健专业人员提供有价值的信息，以应对病毒引起的精子遗传不稳定性及其对生殖健康的影响。此外，它还强调了预防和管理病毒感染的社会经济和公共卫生方面。
