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克服卵巢可视化方面的挑战:一例磁共振成像引导下卵母细胞取卵并成功活产的病例报告。

Overcoming challenges in ovarian visualization: a case report of a magnetic resonance imaging-guided oocyte retrieval resulting in live birth.

作者信息

Neblett Michael F, Kula Hakan, Walker David L, Nunemacher Katherine J, Woodrum David A, Babayev Samir N

机构信息

Division of Reproductive Endocrinology and Infertility, Mayo Clinic, Rochester, Minnesota.

Department of Obstetrics and Gynecology, Dokuz Eylul University School of Medicine, Izmir, Turkey.

出版信息

F S Rep. 2025 Jan 21;6(1):39-46. doi: 10.1016/j.xfre.2025.01.007. eCollection 2025 Mar.

Abstract

OBJECTIVE

To report a successful case of magnetic resonance imaging (MRI)-guided oocyte retrieval in a patient with challenging pelvic anatomy, extensive adhesive disease, and diminished ovarian reserve, necessitated by the inability to visualize the ovaries using transvaginal or transabdominal ultrasound.

DESIGN

Case report.

SUBJECT

A 33-year-old nulligravid woman with a history of ulcerative colitis, multiple pelvic and abdominal surgeries, and significant pelvic adhesive disease.

EXPOSURE

Controlled ovarian stimulation was initiated using a gonadotropin-releasing hormone antagonist protocol, followed by sequential MRI and MRI-guided oocyte retrieval due to challenges in visualizing and accessing the ovaries.

MAIN OUTCOME MEASURES

Successful oocyte retrieval under MRI guidance.

RESULTS

Two oocytes were retrieved from 5 aspirated follicles using MRI guidance. Both underwent intracytoplasmic sperm injection, resulting in the development of a single blastocyst, which led to a live birth via embryo transfer to a gestational carrier.

CONCLUSION

Magnetic resonance imaging-guided oocyte retrieval represents a potential technique for patients with complex pelvic anatomy or extensive adhesive disease, where traditional ultrasound-guided approaches may be inadequate. Interdisciplinary collaboration and individualized care are crucial in optimizing outcomes for patients undergoing assisted reproduction, particularly those with challenging medical histories. Further studies comparing MRI-guided and traditional ultrasound-guided oocyte retrieval in challenging cases are warranted to determine the optimal approach for these patients.

摘要

目的

报告一例磁共振成像(MRI)引导下取卵成功的病例。该患者盆腔解剖结构复杂、存在广泛粘连性疾病且卵巢储备功能减退,经阴道或经腹超声无法清晰显示卵巢,故而需要采用MRI引导取卵。

设计

病例报告。

研究对象

一名33岁未孕女性,有溃疡性结肠炎病史,曾接受多次盆腔和腹部手术,存在严重盆腔粘连性疾病。

干预措施

采用促性腺激素释放激素拮抗剂方案启动控制性卵巢刺激,随后因卵巢可视化和穿刺困难,依次进行了MRI检查及MRI引导下的取卵操作。

主要观察指标

MRI引导下成功取卵。

结果

在MRI引导下,从5个抽吸的卵泡中获取了2枚卵母细胞。两枚卵母细胞均进行了卵胞浆内单精子注射,最终发育成1个囊胚,并通过胚胎移植至妊娠载体实现了活产。

结论

对于盆腔解剖结构复杂或存在广泛粘连性疾病的患者,传统超声引导取卵方法可能不足,而MRI引导下取卵是一种有潜力的技术。跨学科协作和个体化护理对于优化辅助生殖患者的治疗结局至关重要,尤其是对于有复杂病史的患者。有必要开展进一步研究,比较在复杂病例中MRI引导取卵和传统超声引导取卵的效果,以确定针对这些患者的最佳方法。

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